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Path 2 > Benign Soft Tissue > Flashcards

Benign Soft Tissue Flashcards

1
Q

Fibroma is reactive or neoplastic?

A

Reactive to local trauma/irritation

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2
Q

Most common tumor of oral cavity?

A

Fibroma

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3
Q

Fibroma is true neoplasm?

A

no

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4
Q

Histology of fibroma?

A

unencapsulated, collagenized CT covered by SSE

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5
Q

Treatment of fibroma?

A

excision to r/o neoplasm

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6
Q

Recurrence common or rare in fibroma?

A

rare

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7
Q

Fibroma clinical features:
Pigment:
Surface texture:
Sessile/pedunculated?

A

Normal color (can be white from hyperkeratosis)
Smooth
Sessile

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8
Q

Fibromas can be found where in oral cavity?

A

anywhere

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9
Q

Giant cell fibroma important histo feature?

A

Stellate fibroblasts with several nuclei

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10
Q

Variant of giant cell fibroma?

A

Retrocuspid papilla

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11
Q

Retrocuspid papilla location?

A

bilateral, lingual to mand. canines

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12
Q

Pyogenic granuloma aka?

A

Lobular capillary hemangioma, pregnancy tumor

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13
Q

Pyogenic granuloma bad name bc?

A

neither pyogenic or granuloma

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14
Q 
Pyogenic granuloma clinical features?
Surface texture
color
Pedunc or sessile
Pain
Blood
A

Smooth/lobulated
Pedunculated/sessile
Pink/red/purple, ulcerated
Bleeds easily

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15
Q

Pyogenic granuloma new vs old difference

A

Vascular when new, collagenized when old

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16
Q

Pyogenic granuloma location?

A

80% gingiva

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17
Q

Variant of pyogenic granuloma arising in healing extraction socket?
Due to what?

A

epulis granulomatosa due to bony sequestra in socket

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18
Q

Pyogenic granuloma histopath features

A

vascular granulation tissue

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19
Q

Pyogenic granuloma treatment

A

excise and remove irritants

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20
Q

Pyogenic granuloma distinguished how from retrocuspid papilla?

A

Pyogenic granuloma is erythematous or hemorrhagic while retrocuspid papilla is pink, small, and bilateral.

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21
Q

Peripheral giant cell granuloma soft tissue counterpart to what?

A

Central giant cell granuloma

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22
Q

Peripheral giant cell granuloma occurs where

A

Gingiva ONLY

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23
Q

Peripheral giant cell granuloma differs from pyogenic granuloma how?

A

more blue-purple, otherwise similar

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24
Q

Radio features of Peripheral giant cell granuloma?

A

cupping resorption of bone

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25
Q

Peripheral giant cell granuloma origin might be soft or hard tissue, need to workup patient for what?

A

Hyperparathydoidism

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26
Q

Peripheral giant cell granuloma histopath features (cells, deposits, and surface)

A

multinucleated giant cells with background of mesenchymal cells with mitoses, hemorrhage and hemosiderin, ulcerated mucosa overlying

27
Q

Peripheral Ossifying Fibroma occurs where

A

Gingiva ONLY

28
Q 
Peripheral Ossifying Fibroma clinical features
Surface
Color
Type
What can happen to teeth
A

ulcerated, red-pink, Ped/Sess nodule, rare migration and loosening of teeth

29
Q

Peripheral Ossifying Fibroma histopath features

A

fibrous, mineralized product

30
Q

Peripheral Ossifying Fibroma can be easily mistaken for?

A

Pyogenic granuloma

31
Q

Lipoma usually occurs where

A

trunk or extremities, rarely in oral cavity

32
Q

What is #1 most common mesenchymal neoplasm?

33
Q

Lipoma clinical features?

A

soft, smooth, pink/yellow

34
Q

Granular cell tumor found where

A

Oral cavity, usually tongue

35
Q

Granular cell tumor color

A

pink or yellow

36
Q

Granular cell tumor cell differentiation

37
Q

Granular cell tumor histopath features

A

pale, eosinophilic granular cytoplasm

pseudoepitheliomatous hyperplasia

38
Q

Congenital Epulis occurrence/age//location?

A

rare, newborns, alveolar ridge

39
Q

Congenital Epulis resembles?

A

Granular cell tumor

40
Q

Congenital Epulis gender predilection %

A

90% female

41
Q

Congenital Epulis histopath features similar to ? Exception?

A

Similar to granular cell tumor (abundant pale eosinophilic granular cytoplasm) but NO pseudoepitheliomatous hyperplasia

42
Q

Most common peripheral nerve tumor?

A

Neurofibroma

43
Q

Neurofibroma differentiation/histopath?

A

schwann/perineural cells, wavy nuclei, mast cells

44
Q

Neurofibromatosis how many forms? Most common?

A

8, Type 1 most common (90%)

45
Q

Neurofibromatosis causes what disease? Genetic source?

A

von Reck, autosomal dominant chromosome 17

46
Q

Neurofibromatosis clinical features

A

multiple neurofibromas on skin, oral
Cafe au lait pigmentation - smooth macules
Crowe sign - freckles on axilla
Lisch Nodules - brown pigmentation on iris

47
Q

Oral manifestation of Neurofibromatosis?

A

50% enlarged fungiform papillae

48
Q

Schwannoma most common oral site?

49
Q

Schwannoma histopath features

A

encapsulated tumor

50
Q

Schwannoma 2 patterns?

A

Antoni Pattern A - streaming fascicles of spindle Schwann cells palisaded around acellular Veroclay bodies
Antoni Pattern B - random spindle cells in loose myxomatous stroma

51
Q

Traumatic Neuroma happens why

A

transection or damage of nerve bundle leads to proliferation of neural tissue

52
Q

Multiple Endocrine Neoplasia - genetic passing?

A

autosomal dominant

53
Q

MEN Type 2 - three subtypes

A

Familial medullary thyroid carcinoma syndrome
MEN Type 2A
MEN Type 2B

54
Q

MEN Type 2A - conditions (3)

A

Medullary carcinoma of thyroid (MCT) 95%
pheochromocytoma of adrenal medulla 50%
parathyroid hyperplasia/adenoma 25%

55
Q

MEN Type 2B - How related to type 2A?

A

same conditions + multiple mucosal neuromas

56
Q

MEN Type 2B clinical features?

A

Mucosal neuromas on eyes
Oral neuromas - painless papules on lips and anterior tongue.
MCT - ALMOST ALL PATIETNS, aggressive and metastatic, requires prophylactic thyroidectomy before age 1

57
Q

MEN Type 2B first sign of disease?

A

Oral neuromas

58
Q

MCT lab values

A

elevated serum/urinary calcitonin

59
Q

pheochyromocytomas lab values

A

urinary vanillylmandelic acid (VMA) and increase epi to norepi ratio

60
Q

Most common tumor of children

A

hemangioma of infancy

61
Q

Evolution of hemangioma of infancy?

A

proliferate 6-10 months before involution

62
Q

Vascular malformations happen when?

A

present at birth, persist

63
Q

Lymphatic malformation most common site?

Surface?

A

65% in head/neck region
Most common on anterior tongue
Pebbly

64
Q

Lymphatic malformation histopath?

A

proliferation of lymphatic vessels, valves

Path 2 (5 decks)

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