Benign Epithelial Lesions Flashcards
By what method are benign epithelial lesions classified?
Based on their risk of developing into invasive carcinoma
What are nonproliferative breast changes?
Lesions not associated with an increased relative risk
What is proliferative breast disease w/o atypia (and with) associated with?
Developing carcinoma
Non proliferative fibrocystic changes. Characteristic changes?
Cysts form either without epithelial lining or be lined by attenuated epithelium and myoepithelium
By what is is proliferative fibrocystic changes typified?
Increased numbers of cells relative to the basement membrane
The biopsy shows disorderly proliferation of ducts, tubules, and intralobular stromal cells resulting in distortion and expasions of lobules and obliterating duct spaces. What is the Dx?
Sclerosing Adenosis
Angulared glands in a fibroelastotic center surround by a radial distribution of benign ducts and apocrine cysts are shown. What is the Dx?
Radial Scar
The biopsy shows dilated duct spaces containing multiple branching papillae with fibrovascular cores. Dx?
Intraductal Papilloma
Upapillae project into the duct lumen and consist of cells with an increased nuclear:cytoplasmic ratio and nucleear hyperchromasia. What is the Dx?
Atypical Ductal Hyperplasia
What would be the Dx if a patient with atypical ductal hyperplasia shows a duct completely filled with neoplastic cells, and if two duct spaces extending at least 2 mm are involved, what is the Dx?
Low-grade ductal carcinoma insitu
Minimal distension of the lobular acini by a uniform population of cells with intracytoplasmic lumina and round nuclei containing small nucleoli are shown. Dx?
Atypical Lobular Hyperplasia
Lobular neoplastic cells spread into the terminal duct. The atypical cells lie beneath an attenuated surface layer of luminal epithelial cells. What is the process that occured?
Pagetoid spread
The TDLU is enlarged with variably distended acini lined by cuboidal to columnar epithelial cells. What is the Dx?
Flate epithelia atypia
