Benign Breast Flashcards
Breast lymph nodes
most to Axillary, if extensive to supraclavicular Medial/inferior may go to mediastinal
Terminal duct lobular unit Interlobular stroma sensitive to homones
Male Breast No lobules
Resting adult female breast
Pregnancy and lactation Increase lobules
Gynecomastia
Mainly stromal prolif Common benign, but increased risk cancer
Acute Mastitis
Young, lactating, Swollen, red, painful, cracks in nipple, milk stasis Usually staph
Chronic Mastitis
Perimenopausal Not actual bacteral, just plugged by secretions/debris = dilation and inflammation Results in irregular fibrosis (lump)
Periductal Mastitis
Assoc w/ smoking aka recurrent subarolar abcess periductal mastitis Squamous cells grow deep into breast = abscess & often fistula that leaks pus
Fat necrosis
Benign Ill defined mass Early: necrotic fat cells, PMNs Late: macrophages, fibrosis Ca
Fibroadenoma Most common Mobile, regular outline has capsule Stroma prolif = compressed ducts
Lactating Adenoma Prolif of glandular unit In lactating women
Phyllodes Tumor Leaflike structure, large, fleshy Can be benign or if mitoses can be malig
Papilloma Large ducts near nipple Prolif of epithelial fingerlike into the ducts Can cause bloody discharge
Fibrocystic change
Common, 50% of more of people
Some cysts for TDLU
Usually asympotomatic maybe pain and nodules
Often related to cycle of hormones
Nonproliferative vs Proliferative (hyperplasia) vs sclerosing adenosis (no cysts)
Sclerosing Adenosis
Less common, no cysts
Hard & rubbery
Compressed ducts and lumens
Apocrine metaplasia
Assoc w/ fibrocystic change
‘snouts’ intrude into duct
Atypical lobular hyperplasia
If more than 50% lobules involved = carcinoma insitu
If carcinoma risk is bilateral
Moderate ductal hyperplasia
more epithelia just in duct. Florid = duct is filed w/cells
Atypical has ‘punched out’ duct lumens -> greater risk of carcinoma
