Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

POS 3 > Behaviour modifying drugs > Flashcards

Behaviour modifying drugs Flashcards

1
Q

What are serotonergic drugs?

A

SSRIs
increase serotonin by blocking the reabsorption of serotonin and noradrenaline into neurons.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is amitriptyline?

A

serotonergic drug
SRI:NRI 1:4

used for anxiety and pain
has a poor side effect profile

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is clomipramine?

A

serotonergic drug
SRI:NRI 5:1

used for anxiety and compulsion (impulse control, repetitive behaviours)
risk of discontinuation syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is fluoxetine?

A

serotonergic drug
SRI:NRI 15:1

used for anxiety, compulsion, impulsivity, aggression
risk of anorexia
anti-compulsive drug of choice

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is Selegiline?

A

dopaminergic drug
enzyme breaks down dopamine

used for cognitive impairment, specific fear, compulsion, avoidance, fear-related aggression
risk of aggressiveness and confrontation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is Mirtazapine?

A

noradrenergic and specific serotonergic antidepressant
axiolytic
increases motivation, appetite, makes reinforcement easier

used in ppl for GAD, social anxiety, OCD, panic disorder, insomnia, inappetance
risk of discontinuation syndrom and increasing chase behaviour

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is important to consider when prescribing a dopaminergic drug?

A

there must be 2 weeks between it and the last serotonergic drug
needs behavioural support as well

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

When is mirtazapine mostly prescribed?

A

failed response to SSRI
SSRI caused anorexia
generalised anxiety
panic
specific fear

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is Imepitoin?

A

partial benzodiazepine receptor antagonist

an anti-epileptic that is also used as an axiolytic (mixed evidence)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the onset of action of amitriptyline?

A

3-4 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the onset of action of Clomipramine?

A

3.5 to 5 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the onset of action of fluoxetine?

A

4-8 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the onset of action of selegiline?

A

8-10 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the onset of action of mirtazapine?

A

1.5-4 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the onset of action of Imepitoin?

A

1-6 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are the main interactions with Selegiline?

A

SRI/SSRI/TCA
amitraz

17
Q

What are the main interactions with Clomipramine?

A

selegiline
amitraz

18
Q

What are the main interactions with fluoxetine?

A

selegiline
amitraz
NSAIDs (clotting)

19
Q

What are the common adverse effects of SRI/SSRI/TCA?

A

usually seen in first 7-10 days
increased anxiety
sedation
anorexia
irritability

20
Q

How can we help manage the adverse effects of SRI/SSRI/TCA?

A

add appetite stimulant
use anti-nausea
OR
change administration:
- morning vs night
- with a meal
- reduce dose
- switch drug

21
Q

What are the signs of serotonin syndrome?

A

clonus
agitation
tremor
hyperreflexia
hypertonicity
hyperpyrexia
coma, death

22
Q

What is the use of augmentation drugs and the common vet med ones?

A

when mainline drug isn’t doing what we want it to do

trazodone
alpha2adrenoreceptor agonist
gabapentin
B-adrenoreceptor antagonist (propranolol)
memantine

23
Q

What is Trazodone?

A

serotonin receptor agonist and reuptake inhibitor

adjunct therapy for many problems but NOT aggression
short term anxiolytic

24
Q

What is Clonidine?

A

alpha2 adrenoreceptor agonist

potential augmentation therapy with SSRIs especially for short planned events
no effect on appetite

25
Q

What is Demedetomidine?

A

alpha2 adrenoreceptor agonist
minimal sedation, no effect on cognition

26
Q

What is Propranolol?

A

beta adrenoreceptor blocker

useful for situational anxiety and social phobia
commonly used adjunct therapy
no effect on appetite

27
Q

What is Memantine?

A

antagonist of glutamatergic NMDA receptors

used for tx of pain and alzheimers
improves attention and cognition
used as an augmentation for OCD
most effective with fluoxetine for compulsive behaviour

28
Q

What is Gabapentin?

A

GABA analogue

used for pain, anxiety, acute anxiety

29
Q

When would you decide to use a combination of drugs?

A

when onset of action of main drug is too slow or to deal with high intensity events

main drug isnt working well enough

add effect that main drug doesn’t produce

30
Q

How can diet help when the main drug isn’t working well enough?

A

can affect efficacy
fibre level (high fiber reduces absorption)
protein:carbohydrate balance
fish oil content (DHA)

31
Q

How do we evaluate if main drug isn’t working well enough?

A

misdiagnosis? new problem? health problem? stressors? diet change?
review response every 60 days

no effect: switch drugs
partial effect: increase dose or add drug
good effect: continue drug

32
Q

How can we properly explain behavioural improvement expectations to clients?

A

increase monitoring and recording events
set realistic expectations for the drug
ask to evaluate key masures: % of events dog reacts to, severity of response

33
Q
A

POS 3 (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions