Behavioral Health Flashcards
What is first-line treatment for this condition for PMS?
Fluoxetine
When do symptoms of PMS or PMDD occur?
later luteal phase
four or five prior to menses
and remit after menses
MC affective/behaviroal sx PMS/PMDD
MC mood swings
Lab testing that should be done when working up possible PMS/PMDD
Thyroid studies
First line tx PMS/PMDD
SSRIs can be administered either
- continuously
- only during the luteal phase (start on day 14 of cycle)
- monthly only when symptomatic
Second line tx for PMS/PMDD
Oral contraceptives that contain drospirenone (progestin) best
Can also be used in adjunct with SSRI
What PMS is suggested when someone fails SSRI/oral contraception combo tx
Gonadotropin releasing hormone agonist tx such as
LEUPROLIDE
When this is done the provider usually then will “add-back therapy” with estrogen and progestin to avoid menopausal sx and osteoporosis
What is the last line tx for PMS/PMDD
surgery with oophorectomy
Tx for moderate to severe PMS/PMDD
SSRI
Oral contraceptives containing drosperinone
Continuous contraceptive containing any progestin
Alprazolam
GrRH
Ineffective tx for PMS/PMDD
progesterone
vitamin supplements
dietary restriction
What are the adverse effects of GnRH agonists?
bc of hypoestrogenism:
hot flashes, vaginal atrophy, decreased BMD
Name a med that can be used when someone with schizophrenia has an acute psychotic episode
Olanzipine
RF for schizophrenia
living in urban area immigration obstetric complications late winter or early spring birth (poss. exposure to influenza during neural tube development) increased paternal age at conception
Schizophrenia positive sx
Added to the personality: hallucinations delusions disorganized speech disorganized behavior
Schizophrenia negative sx
Take away from the personality: blunted/flat affect alogia or impoverished speech anhedonia (lack pleasure) social withdrawl
Dx of schizophrenia can be made by…
when at least two or more of the characteristic symptoms, including delusions, hallucinations, disorganized speech, disorganized behavior, and negative symptoms, are present most of the time for at least one month (or less if treated)
Dx of schizophrenia is confirmed at 6 months by….
Signs of disturbance must persist for at least six months (with at least one month of two of the five symptoms) to confirm the diagnosis. During the remainder of the six month period, the clinical manifestations may be limited to only negative symptoms or less severe positive symptoms that are not causing social or occupational dysfunction
Do antipsychotics work better on positive or negative sx of schizophrenia
positive
Which antipsychotic has the best efficacy and why is it not used first
clozapine
causes agranulocytosis
reserved for those who fail to improve or can not tolerate the other antipsychotics
Which antipsychotic is the only one effective for the negative sx of schizophrenia
cariprazine
Which generation of antipsychotics cause the least extrapyramidal SE
Second generation
What are the extrapyrimidal SE
akathisia rigidity bradykinesia tremor acute dystonic rxns
How long does it take for an antipsychotic to improve positive sx of schizophrenia
Most effect seen in first 2 weeks
Continues to improve over months
What initial intervention should you do if an antipsychotic isn’t working for your schizophrenic pt
increase the dose
Or
switch to a different antipsychotic
How do you treat a person with schizophrenia having agitated psychosis
usually works in minutes
antipsychotic med like risperidone, olanzapine, haloperidol
w/ or w/o
benzo like lorazepam
Why would benztropine of diphenhydramine be given to someone experiencing agitated acute psychosis?
To blunt the extrapyramidal SE of the antipsychotic meds
With what and for how long should you treat someone who has had a psychotic event (even just one)
antipsychotic med at lowest dose possible indefinitely
Name the first gen antipsychotics
MOA
SE
MOA: dopamine antagonists
haloperidol, fluphenazine, chlorpromazine
SE: extrapyramidal sx, sedation, anticholinergic, orthostatic hypotension, agranulocytosis, tardive dyskinesia, hyperprolactenemia, NMS, prolonged QT interval, metabolic syndromes
Define tardive dyskinesia
involuntary choreoathetoid movements of the mouth, tongue, face, extremities, or trunk
Name metabolic syndrome features
Weight gain
DM
dyslipidemia
cardiovascular disease
These two AE effects do not usually occur when using a second gen antipsychotic
extrapyramidal
tardive dyskinesia
Name some anticholinergic effects
dry mouth, constipation, urinary retention, blurred vision
What is the MOA of second gen antipsychotics
dopamine and serotonin antagonists