Behavioral

Question 1

clomiprimine

Answer 1

• daily drug
• tricyclic antidepressant (TCA)
• for separation anxiety, OCD, aggression, urine
• t 1/2 long, 2-9h fed, 3-21h fasted
• FDA approved; more side effects than SSRI’s; alpha 1 and NE activityl; do not use on cardiac patients; arrhythmia side effect; urinary retentation, pupllary dilation

Question 2

fluoxetine *

Answer 2

• daily drug
• selective serotonin reuptake inhibitor (SSRI)
• for anxiety, OCD, aggression, urinary marking
• t 1/2 6h
• Prozac in humans; FDA approved in dogs; no longer available, generic available, nor-fluoxetin 49h in dogs; dogs can become aggressive; first-line for daily treatment

Question 3

selegiline

Answer 3

• monoamine oxidase inhibitor (MAOI)

- FDA approved for Cushing’s disease and ‘Old Dog Dementia’; data not compelling

Question 4

alprazolam (Xanax)

Answer 4

• bzd/ event drug
• GABA alpha receptor
• Dr. Neilson’s favorite; give 1-2 hours before event

Question 5

clonidine

Answer 5

• alpha 2 adrenergic agonist
• PRN or BID
• anti-hypertensive in humans

Question 6

trazadone

Answer 6

• event drug (supplem)
• serotonin antagonist and reuptake inhibitor (SARI)
• for canine anxiety disorder
• can use with SSRI or TCA