Before Midterm 2 Flashcards
Biologyical psychologist/neuroscientists
Study the brain and behaviour
Phrenology
Studying the structure of brain and heavier
-shape, size and protrusions
-mapped out portions of the brain
Phrenology believed that protrusions of the cranium meant…
That certain people had larger parts of the brain
-smarter in those areas
Phrenology: where there are differences between people there must also be..
Structural brain differences between them
How was phrenology disproven
When found that damage to areas that should correspond to certain traits mapped out, did not in fact
-the brain is not just one region, it is rather a connection of multiple areas articulating together
Electrical stimulation studies
Investigating brain function, by electrically stimulating the brain during neurosurgery
Who was the American-Canadian neurosurgeon, integral to electrical stimulation studies
Wilder Penfield
ESS supported the idea that neural communication is ____ in nature
Electrical
Wilder Penfield
Mapped brain cortex
-using electrical stimuli’s on a certain location
-a lot of poking and guessing
ESS was not interested in:
The consequences of “poke and guess”
Lesion studies
Created damage to a specific area to understand impairment
Electroencephalography (EEG)
Recording of the brains electrical activity at the surface of the skull
-like a capsule with all the cords/buttons
-created a spreadsheet of region:response
EEG advantages/disadvantages
A- noninvasive, high temporal resolution
D- no information in individual cell activity, or accurate region activity
Computed tomography (CT scan)
Multiple X-rays to build a 3D reconstitution of the brain
CT scan advantage/disadvantage
A- detects dense tissue
D- static image, doesn’t show activity over time
Positron Emission Tomography (PET scan)
Since an active brain requires glucose, attach radio to bind with glucose to see what part of the brain is using glucose (active) and when
PET scan advantage/disadvantage:
A- helpful for isotope drugs and seeing where they are used
D- invasive, static image, poor spatial resolution
Structural MRI
Uses magnetic fields to indirectly visualize Brian structure
What is better at detecting soft tissue (MRI or CT)
MRI
MRI advantages/disadvantages
A- better soft tissue detection, higher spatial resolution
D- expensive, static, no activity over time
FMRI (functional magnetic resonance imaging)
Detects the changes in blood oxygenation + flow that occur in response to neural activity
-vibrates the iron in blood
FMRI advantages/disadvantages
A- activity over time is represented, spatial resolution
D- poor temporal resolution, expensive
Magnetoencephalography (MEG)
Measures brain activity by detecting tiny magnetic fields generated by the brain
MEG advantages/disadvantages
A- good temporal, and spatial
D- not good at detecting deep activity, expensive, technologically difficult
Deep brain stimulation (DBS)
Battery powered electrodes are implanted in brain, which shows electrical stimulation in certain areas
-neuropsychological conditions
DBS advantage/disadvantages
A- treat neuropsychological conditions
D- very invasive, general surgery risks, lack of control once implanted
Transcranial magnetic stimulation (TMS)
Strong/quick magnetic field to surface of skull
-interrupt or enhance brain function/signal
TMS advantage/disadvantage
A- Inhibits neural function for moments
D- can cause seizures, only operates on cortex
Localization of function
When certain brain areas are found to be particularly active during a specific psychological task
Electrical process
Occurs inside neuron
Chemical process
How one cell communicates with another cell
Neuron
-ns cell
sends messages from one area to another using electrical/chemical process
Parts of neuron
-cell body
-dendrites
-axon
-axon terminal
Cell body/soma
Contains nucleus and cell membrane
-keeps cell alive and functioning
Dendrites
-growing out of soma
-capture signals from outside neuron
-chemicals bind onto receptor sites to activate a response
Axon
“Cell toso”
-contains myelin sheath and nodes of ranvier
-push signal away from neuron (cell body)
Axon terminals
Electrical signal will release chemicals into synaptic space from axon terminals
Neural communication occurs due to
Synaptic junction
Chemical information is transferred at the
Synapse
Glial cells
Cells in the nervous system
-supports neurons and neuronal functioning
Astrocytes
Responsible for BBB
Oligiodendrocyte
Responsible for myelin sheath of some axons
Myelin sheath
Collection of fatty tissue attached to axon
-highly conductive
Myelinated neurons
Pass signal along axon much faster than unmyelinated neurons
MS, Parkinson’s
Demyelination diseases
-results in motor problems
Action potential
The formation of the electrical impulse
-neuron has fired
Resting potential
Neuron is not signaled or isn’t firing
-voltage charge is relative to outside solution
-consistent
Resting potential charge:
-70 mv
Threshold
A value that needs to be met to create an action potential
-all or nothing
Depolarization
Action potential is generating
-positive
Depolarization number
40mv
Repolarized
Cell is “refreshing” to repeat actions of AP
-getting more negative
Hyperpolarixation
Cell drops even more negative than resting potential
Absolute refractory period
Cell returning back to baseline (repolarization)
-cannot active or generate new impulse
Relative refractory period
if gets enough (usually more) stimulation will reactive
-hyperpolarization/below resting potential
-needs 25mv
Generally speaking how much electrical stimuli’s needs to reach threshold (from -70mv)
Needs 15mv
How long is an action potential
1s
All or none law
The cell either fires or does not fire
-no half measures
-stronger signals do not cause stronger AP
What does a stronger signal do
Creates MORE action potential
-rate of firing is increased
Chemical neuron communications
-occurs among neurons
-neurotransmitters bind to receptor sites on densities of post synaptic neuron
Neurotransmitters
Chemical substances that carry messages across the synapse
-excite
-inhibit
Five steps of chemical communication in order
-synthesis
-storage
-release
-binding
-deactivation
Two broad categories of neurotransmitters
-excitatory (depolarization)
-inhibitory (hyperpolarization)
Excitatory postsynaptic potentials (EPSP)
Postynaptic depolarization
-postsynaptic neuron more likely to fire
-toward threshold
Inhibitory postsynaptic potentials (IPSPP)
Postsynaptic hyperpolarization
-postsynaptic neuron less likely to fire
-further from threshold
Presynaptic neuron sends chemical signal to
Postsynaptic neuron
Synthesis
Building neurotransmitters in the vessel
storage
Storage in synaptic vesicles
Release
Release into synaptic space
Binding
Binding to receptor sites
Deactivation
Deactivation through or reputable of breakdown
-chemicals can float back inside
Role of excitatory and inhibitory neurotransmitters
Ensure action potential is reached, and that there is a period of time for the cell to refresh
EPSP receptor
A or B
IPSP receptor
D or E
Glutamate
Main excitatory NT
-sensory and learning
-alcohol and sensory enhancers
GABA
Main inhibitory NT
-alcohol and anti anxiety
Norepinephrine
Cortical arousal
-amphetamine and methamphetamine
Acetylcholine
Cortical arousal, selective attention, memory (Alzheimer’s), muscle contradiction
-nicotine, memory enhancers, Botox
Dopamine
Motor function, reward and pleasure
-L dopa used to treat Parkinson’s disease, antipsychotics (hallucinations)
Serotonin
Mood regulation, aggression, sleep wake cycles and temperature
-SSRI anti depressants
Endorphins
Pain killers
-codeine, morphine, heroine
Anandamide
Pain killers, increase in appetite
-tetrahydrocannabinol (weed)
Psychoactive drugs
Drugs that impact the nervous system
Drugs can be either
Agonist or antagonist
Agonist
Drug enhances activity at the receptor site
-binds to receptor site or blocks reuptake
Antagonist
Drug reduces activity at the receptor site
-binds to receptor site and blocks neurotransmitters
Neural plasticity
Ability of neurons to change over time
-structural or functional
Networks of neurons in the brain change over the course of development in four primary ways
-growth
-synaptogenesis
-pruning
-myelination
Synaptogenesis
Creation of new synapses
Neurogensis
Repairing brain damage
-only happens sometimes
Stem cells
Undifferentiated cells
-have capacity to become any type of cell in the body
Three areas related to neural plasticity
-developmental
-learning
-following injury and or degeneration
Plasticity and development
When an individual’s brain is growing during early years
Myelination
Speeding up communication between neurons
-usually heavily used neurons
Growth
Early aged individuals don’t have as many differentiated cells, and shorter dendrites
So…
-neurons grow dendrites (more receptor sites)
-axons extend on neurons
Synaptogenesis
More synapses
-with growth of dendrites and axons, more axon terminals are grown
Pruning
Process of the brain filtering unnecessary neurons
-due to rapid periods of growth and chaos
-enhances efficient
CNS
Brain and spinal cord
Brain is made up of
-forebrain
-midbrain
-hindbrain
Forebrain is made up of
-cerebral cortex
-basal ganglia
-limbic system
Hindbrain is made up of
-Cerebellum
-brain stem
Brain stem is made up of
-pons
-medulla
Plasticity and learning
-creation of new synapses
-memory function and activation
The brain changes as we learn
Potentiation
The change of the structure and activation patterns of neurons due to repetitive stimulation
-emphasizing the certain activity that is used more
Structural plasticity
Neurons change shape as a function of activation
-neurons will be physically larger with more stimulation (enrichment)
Limbic system is made up of
-Hippocampus
-amygdala
-nucleus accumbens
-thalamus
-hypothalamus
PNS
Somatic and autonomic
Somatic system
Voluntary muscle activation
-sensory and motor nerves
Plasticity in injury and degeneration
Sometimes neural connections of brain regions can take place of others
-neural genesis
Neurogenesis
Idea that individuals can regrow and repair damaged neurons
-mostly in hippocampus
-not very common
Theorized way of fixing damage to brain, using stem cells
Implantation of stem cells, can induce them to differentiate and repair/replace damaged areas
Autonomic system controls
-smooth muscle, cardiac muscle, glands
-involuntary
Autonomic system makes up
Sympathetic and parasympathetic
Spinal cord
-connects peripheral ns with the brain
-relays information from body to brain, then back down
-contains spinal reflexes
Spinal reflexes
Various spinal nerves that bundle together to relay reflexes
Damage to spinal cord
Will absolutely sever any function related to that area
-paralysis
Spinal cord is protected by
Vertebrae
Pathway to brain from receptor
Receptor—> sensory—> interneuron—> motor neuron —> reaction
Cerebral cortex
The outer wrinkly layer of the brain
-divided into two hemispheres
Hemispheres are connected via the
Corpus callosum
Left hemisphere of the cortex majors in
-fine tuned language skills
-motor actions
Right hemisphere cortex majors in
-coarse language
-visuospatial skills
Lobes of the cortex
-frontal
-parietal
-temporal
-occipital
Frontal lobe
-motor function
-organization
-language
-memory
Parietal lobe
Sensory
-touch, temp, pain, perception
Temporal lobe
Auditory processing
Occipital lobe
Visual processing
What separates frontal and parietal lobe
Central sulcus
Basal ganglia
Motor function
-collections of neurons
-damage results in tremors or involuntary movements
Amygdala
Emotional response: aggression or fear
-fight or fight
Hippocampus
Memory
Hypothalamus
Survival skills, and homeostasis
-hunger, sex drive, temperature
Thalamus
Relay station/motor function
Midbrain function
-eye movement and coordination
-RAS (reticular activating system)
RAS function
Conscious awareness
-control over existence
-regulates sleep, wakefulness and attention
Eg- general anthestetic
Medulla oblongata
Breathing, swallowing, digestion
-damage usually means death