BD: Biochemistry of Bone Formation Flashcards
- What are the four phases of skeletal development?
a. 1. Migration
b. 2. Interaction
c. 3. Mesenchymal condensation
d. 4. Differentiation
- What are the two types of bone formation?
a. 1. Endochondral
b. 2. Intramembranous
- Which bone formation type is indirect?
Endochondral
What occurs in endochondral bone formation?
The bone starts as cartilage
What bones are usually endochondral?
Bones that bear weight
What bone formation is direct?
Intramembranous
- Why is it intramembranous bone formation direct?
Because the mesenchymal cells become osteoblasts with no cartilage intermediate
- Where is intramembranous bone formation restricted at?
a. It is restricted to the cranial vault and facial bones
- What molecules attract hypertrophic chondrocytes to blood vessels to invade?
VEGF
- When does growth plate fusion occur?
Age 14-20
- When do secondary ossification centers appear?
a. Around the time of birth
- What is the first type of bone produced?
a. Woven bone/Primary bone
- When is woven bone most often found?
During fractures
What is woven immature bone replaced with?
Lamellar bone
What can lamellar bone be classified into?
- Compact bone
- Cancellous bone
What are the three main bone cell types?
- Osteoclasts
- Osteoblasts
- Osteocytes
What is unique about osteoblasts, chondroblasts, myoblasts, and adipocytes?
They all originate from a mesenchymal progenitor
What type of collagen is produced from osteoblasts?
Type 1
What are the two transcription factors used in osteoblasts?
RUNX2
Osterix
What are the extracellular matrix proteins used in osteoblasts?
Type 1 collagen
Osteopontin
Osteocalcin
Bone sialoprotein