BB DAY 1 RH blood group system Flashcards by Shaila Silo

inheritance of 3 genes
each gene codes for an antigen

a. Fisher-race
b. wiener
c. rosenfield
d. ISBT

a. Fisher-race

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inheritance of 1 gene
gene codes for an AGGLUTINATION
each agglutinogen contains 3 blood factor

a. Fisher-race
b. wiener
c. rosenfield
d. ISBT

b. wiener

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only indicates the presence or absence of Rh antigens

a. Fisher-race
b. wiener
c. rosenfield
d. ISBT

c. rosenfield

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adopted six digit number for each blood group specificity

a. Fisher-race
b. wiener
c. rosenfield
d. ISBT

d. ISBT

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rouleaux resolution:

wash red cells 2-3x
wash cord cells 6-8x

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how to diff. rouleaux from agglutination

add drops of NSS

it will disprese rouleaux
true agglutination will remain INTACT

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D antigens expressed appear to be complete, but few in number

a. GENETIC WEAK D
b. D MOSAIC OR PARTIAL D
c. C TRANS

a. GENETIC WEAK D

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one or more parts of the D antigen is missing

a. GENETIC WEAK D
b. D MOSAIC OR PARTIAL D
c. C TRANS

b. D MOSAIC OR PARTIAL D

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position effect or gene interaction effect

a. GENETIC WEAK D
b. D MOSAIC OR PARTIAL D
c. C TRANS

c. C TRANS

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An antigen present on most D-positive and all C-positive RBCs:

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when the complement is not activated or incompletely activated

extravascular hemolysis
intravascular hemolysis

extravascular hemolysis

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when the complement is completely activated

extravascular hemolysis
intravascular hemolysis

intravascular hemolysis

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immediate intravascular hemolysis

ABO HTR
RH HTR

ABO HTR

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delayed extravascular hemolysis

ABO HTR
RH HTR

RH HTR

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most common HDN

ABO HDN
RH HDN

ABO HDN

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SEVERE HDN

ABO HDN
RH HDN

RH HDN

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cannot be diagnosed

ABO HDN
RH HDN

ABO HDN

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followed with titers

ABO HDN
RH HDN

RH HDN

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can affect second child

ABO HDN
RH HDN

RH HDN

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can affect first child

ABO HDN
RH HDN

ABO HDN

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occurs in group type O mothers

ABO HDN
RH HDN

ABO HDN

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can affect any Rh negative mother

ABO HDN
RH HDN

RH HDN

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slight rise in bilirubin (TREAT WITH PHOTOTHERAPY)

ABO HDN
RH HDN

ABO HDN

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high rise in bilirubin (MAY NEED TO PERFORM EXCHANGE TRANSFUSION)

ABO HDN
RH HDN

RH HDN

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Rh antibodies are predominantly:

IgG

Rh antibodies rbc destruction are:

EXTRAVASCULAR

Rh Immune Globulin/RhIg has two primary uses

treatment of ITP/Immune thrombocytopenic purpura prevention of Rh HDN

Rh Immune Globulin/RhIg If the screening test is NEGATIVE for the presence of D-positive RBCs of fetal origin

the mother shoud received a full dose of RhIg within 72 hours of delivery

Rh Immune Globulin/RhIg If the screening test is POSITIVE:

the FMH/Fetomaternal hemorrhage must be quantified using the Kleihauer-Betke test

used to quantitate the number of fetal Rh-positive cells in the mothers circulation as a result of Fetomaternal hemorrhage

Kleihauer-Betke test or Flow Cytometry

storage of rhogam:

1-6C

shelf life of of rhogam:

2 years

If a person has the genetic makeup Hh, AO, LeLe, sese, what substance will be found in the secretions?

Lea substance

What techniques are necessary for weak D testing?

37°C incubation + indirect antiglobulin test

weak D antigen are recognized only by an

IAT/ Indirect Antiglobulin Test

The glass surface of an Rh viewbox should be _____ C

Between 45 and 50C

in RH viewbox, read for CLUMPING within

2 minutes

lacks C/c and E/e antigens

D deletion

designated as D--/D--

D deletion

lacks of all Rh antigens on their rbcs

Rh null

designated as ---/---

Rh null

lewis antigens related tumor marker

Ca 19-9

not synthesized by the RBCs produced only by tissue cells

Lewis antigens

Lewis antigens phenotype

Le(a-b-)

DECREASED in expression during PREGNANCY

Lewis antigens

IgM, naturally occurring, do not cause HDN

Lewis ANTIBODIES

Lewis ANTIBODIES Ig:

IgM

Frequently encountered in pregnant wimen

Lewis ANTIBODIES

most frequently encountered of the lewis antibodies and is often detected in room temperature tests

Anti-Lea

screening for Fetomaternal Hemorrhage

Rosette test/Du Rosette

Quantifying Fetomaternal Hemorrhage

Kleihauer-Betke test Flow Cytometry Enzyme Linked Antiglobulin Test

The antigen system closely associated phenotypically with Rh is known as:

LW/Landsteiner Wiener

cis-product antigen; c and e are inherited as a haplotype

found in 30% of blacks and <1% of whites

occurs in 32% in blacks

Rh antibodies react best at what temperature (°C)?

Of the red cells listed, which has the most D antigen present? Rh null D positive dce/dce D- - / D - -

D- - / D - -

ABO antibodies in infants are detected in serum:

3 to 6 months after birth

Rh immune globulin provides ____ protection against fetal D antigen.

Passive

Which of the blood group systems is associated with antibodies that are generally IgM?

Lewis

Rh positive refers to the presence of

D antigen

refers to the absence of the D antigen

Rh negative