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BB > BB DAY 1 RH blood group system > Flashcards

BB DAY 1 RH blood group system Flashcards

1
Q

inheritance of 3 genes
each gene codes for an antigen

a. Fisher-race
b. wiener
c. rosenfield
d. ISBT

A

a. Fisher-race

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2
Q

inheritance of 1 gene
gene codes for an AGGLUTINATION
each agglutinogen contains 3 blood factor

a. Fisher-race
b. wiener
c. rosenfield
d. ISBT

A

b. wiener

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3
Q

only indicates the presence or absence of Rh antigens

a. Fisher-race
b. wiener
c. rosenfield
d. ISBT

A

c. rosenfield

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4
Q

adopted six digit number for each blood group specificity

a. Fisher-race
b. wiener
c. rosenfield
d. ISBT

A

d. ISBT

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5
Q

rouleaux resolution:

A

wash red cells 2-3x
wash cord cells 6-8x

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6
Q

how to diff. rouleaux from agglutination

A

add drops of NSS

it will disprese rouleaux
true agglutination will remain INTACT

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7
Q

D antigens expressed appear to be complete, but few in number

a. GENETIC WEAK D
b. D MOSAIC OR PARTIAL D
c. C TRANS

A

a. GENETIC WEAK D

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8
Q

one or more parts of the D antigen is missing

a. GENETIC WEAK D
b. D MOSAIC OR PARTIAL D
c. C TRANS

A

b. D MOSAIC OR PARTIAL D

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9
Q

position effect or gene interaction effect

a. GENETIC WEAK D
b. D MOSAIC OR PARTIAL D
c. C TRANS

A

c. C TRANS

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10
Q

An antigen present on most D-positive and all C-positive RBCs:

A

G

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11
Q

when the complement is not activated or incompletely activated

extravascular hemolysis
intravascular hemolysis

A

extravascular hemolysis

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12
Q

when the complement is completely activated

extravascular hemolysis
intravascular hemolysis

A

intravascular hemolysis

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13
Q

immediate intravascular hemolysis

ABO HTR
RH HTR

A

ABO HTR

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14
Q

delayed extravascular hemolysis

ABO HTR
RH HTR

A

RH HTR

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15
Q

most common HDN

ABO HDN
RH HDN

A

ABO HDN

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16
Q

SEVERE HDN

ABO HDN
RH HDN

A

RH HDN

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17
Q

cannot be diagnosed

ABO HDN
RH HDN

A

ABO HDN

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18
Q

followed with titers

ABO HDN
RH HDN

A

RH HDN

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19
Q

can affect second child

ABO HDN
RH HDN

A

RH HDN

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19
Q

can affect first child

ABO HDN
RH HDN

A

ABO HDN

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20
Q

occurs in group type O mothers

ABO HDN
RH HDN

A

ABO HDN

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21
Q

can affect any Rh negative mother

ABO HDN
RH HDN

A

RH HDN

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22
Q

slight rise in bilirubin (TREAT WITH PHOTOTHERAPY)

ABO HDN
RH HDN

A

ABO HDN

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23
Q

high rise in bilirubin (MAY NEED TO PERFORM EXCHANGE TRANSFUSION)

ABO HDN
RH HDN

A

RH HDN

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24
Q

Rh antibodies are predominantly:

A

IgG

25
Q

Rh antibodies rbc destruction are:

A

EXTRAVASCULAR

26
Q

Rh Immune Globulin/RhIg has two primary uses

A

treatment of ITP/Immune thrombocytopenic purpura

prevention of Rh HDN

27
Q

Rh Immune Globulin/RhIg

If the screening test is NEGATIVE for the presence of D-positive RBCs of fetal origin

A

the mother shoud received a full dose of RhIg within 72 hours of delivery

28
Q

Rh Immune Globulin/RhIg

If the screening test is POSITIVE:

A

the FMH/Fetomaternal hemorrhage must be quantified using the Kleihauer-Betke test

29
Q

used to quantitate the number of fetal Rh-positive cells in the mothers circulation as a result of Fetomaternal hemorrhage

A

Kleihauer-Betke test or Flow Cytometry

30
Q

storage of rhogam:

A

1-6C

31
Q

shelf life of of rhogam:

A

2 years

32
Q

If a person has the genetic makeup Hh, AO, LeLe, sese, what substance will be found in the secretions?

A

Lea substance

33
Q

What techniques are necessary for weak D testing?

A

37°C incubation + indirect antiglobulin test

34
Q

weak D antigen are recognized only by an

A

IAT/ Indirect Antiglobulin Test

35
Q

The glass surface of an Rh viewbox should be _____ C

A

Between 45 and 50C

36
Q

in RH viewbox, read for CLUMPING within

A

2 minutes

37
Q

lacks C/c and E/e antigens

A

D deletion

38
Q

designated as D–/D–

A

D deletion

39
Q

lacks of all Rh antigens on their rbcs

A

Rh null

40
Q

designated as —/—

A

Rh null

41
Q

lewis antigens related tumor marker

A

Ca 19-9

42
Q

not synthesized by the RBCs produced only by tissue cells

A

Lewis antigens

43
Q

Lewis antigens phenotype

A

Le(a-b-)

44
Q

DECREASED in expression during PREGNANCY

A

Lewis antigens

45
Q

IgM, naturally occurring, do not cause HDN

A

Lewis ANTIBODIES

46
Q

Lewis ANTIBODIES Ig:

A

IgM

47
Q

Frequently encountered in pregnant wimen

A

Lewis ANTIBODIES

48
Q

most frequently encountered of the lewis antibodies and is often detected in room temperature tests

A

Anti-Lea

49
Q

screening for Fetomaternal Hemorrhage

A

Rosette test/Du Rosette

50
Q

Quantifying Fetomaternal Hemorrhage

A

Kleihauer-Betke test
Flow Cytometry
Enzyme Linked Antiglobulin Test

51
Q

The antigen system closely associated phenotypically with Rh is known as:

A

LW/Landsteiner Wiener

52
Q

cis-product antigen; c and e are inherited as a haplotype

A

f

53
Q

found in 30% of blacks and <1% of whites

A

V

54
Q

occurs in 32% in blacks

A

VS

55
Q

Rh antibodies react best at what temperature (°C)?

A

37

56
Q

Of the red cells listed, which has the most D antigen present?

Rh null
D positive
dce/dce
D- - / D - -

A

D- - / D - -

57
Q

ABO antibodies in infants are detected in serum:

A

3 to 6 months after birth

58
Q

Rh immune globulin provides ____ protection against fetal D antigen.

A

Passive

59
Q

Which of the blood group systems is associated with antibodies that are generally IgM?

A

Lewis

60
Q

Rh positive refers to the presence of

A

D antigen

61
Q

refers to the absence of the D antigen

A

Rh negative

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