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BLOOD BANKING > BB D-1 > Flashcards

BB D-1 Flashcards

1
Q

What type of serological testing does the blood bank technologist perform when determining the blood group of a patient?

A

PHENOTYPING

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2
Q

Which genotype(s) will give rise to the Bombay phenotype?

A

hh only

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3
Q

Which of the following describes the expression of most blood group antigens?

A

CODOMINANT

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4
Q

What blood type is not possible for an offspring of an AO and BO mating?

A

AB, A, B, O

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5
Q

A patient’s serum is incompatible with O cells. The patient RBCs give a negative reaction to anti-H lectin. What is the most likely cause of these results?

A

THE PATIENT MAY BE A BOMBAY

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6
Q

What antibodies are formed by a Bombay individual?

A

ANTI-A, ANTI-B, AND ANTI-H

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7
Q

Acquired B antigens have been found in

A

GROUP A PERSONS

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8
Q

Which typing results are most likely to occur when a patient has an acquired B antigen?

A

Anti-A 4+, anti-B 1+, A1 cells neg, B cells 4+

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9
Q

Which blood group has the LEAST amount of H antigen?

A

A1B

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10
Q

What should be done if all forward and reverse ABO results are negative?

A

Incubate at 22°C or 4°C to enhance weak expression

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11
Q

N-acetyl-D-galactosamine is the immunodominant carbohydrate that reacts with:

A

Dolichos biflorus

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12
Q

A stem cell transplant patient was retyped when she was transferred from another hospital. What is the most likely cause of the following results?

A

IMMUNODEFICIENCY

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13
Q

A complete Rh typing for antigens C, c, D, E, and e revealed negative results for C, D, and E. How is the individual designated?

A

Rh NEGATIVE

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14
Q

A patient tests positive for weak D but also appears to have anti-D in his serum. What may be the problem?

A

A D mosaic may make antibodies to missing antigen parts

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15
Q

What does the genotype —/— represent in the Rh system

A

Rh NULL

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16
Q

What techniques are necessary for weak D testing?

A

37°C incubation + indirect antiglobulin test

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17
Q

Which of the following sugars must be present on a precursor substance for A and B antigenic activity to be expressed?

A

L-FUCOSE

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18
Q

Lectins are useful in determining the cause of abnormal reactions in blood bank serology. These lectins are frequently labeled as anti-H, anti-A1 etc. The nature of these lectins is explained by which of the following?

A

A plant substance that chemically reacts with certain RBC antigens

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19
Q

If a patient has the Rh genotype DCe/DCe and receives a unit of red blood cells from a DCe/dce individual, what Rh antibody might the patient develop?

A

ANTI-c

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20
Q

Which of the blood group systems is associated with antibodies that are generally IgM?

A

LEWIS

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21
Q

Associated with Group 1 ABO discrepancies

A

Subgroups of A or B

22
Q

An antigen present on most D-positive and all C-positive RBCs:

A

G

23
Q

From the following ABO mating, what are the probabilities of the ABO PHENOTYPES of potential offspring? Mother: Group O; Father: Group B (heterozygous).

A

50% B, 50% O

24
Q

Rh antibodies are predominantly

A

IgG

25
Q

Rh immune globulin provides ____ protection against fetal D antigen.

A

PASSIVE

26
Q

If an Rh negative woman recently delivered an Rh positive baby and the Kleihauer-Betke test result is 5%, how many vials of Rh Ig should be administered?

A

9

27
Q

The glass surface of an Rh viewbox should be _____ C.

A

BETWEEN 45 and 50C

28
Q

Anti-c can be formed by persons with the genotype

A

R1R1

29
Q

The results of a Kleihauer-Betke stain indicate a feto-maternal hemorrhage of 35 mL of whole blood. How many vials of Rh immune globulin would be required?

A

2

30
Q

ABH substances would be found in the saliva of a group B secretor:

A

B and H

31
Q

The immunogenicity of the common Rh antigens may be described from greatest to least:

A

D>c>E>C>e

32
Q

An individual with genes A, H, Se and lele has which of the following phenotypes?

A

AH, Le (a-b-)

33
Q

The antigen system closely associated phenotypically with Rh is known as:

A

LW

34
Q

“O” secretor person would demonstrate what substance/s in his saliva:

A

H

35
Q

Which of the following is NOT true about the anti-A and anti-B?

A

They are well-developed at birth

36
Q

What chain is formed when the terminal galactose on the ABH precursor substance is attached to the N-acetylglucosamine in beta 1, 4 linkage?

A

Type 2 precursor chain

37
Q

Rh-HDN occurs in what type of mother and child

A

Mother is Rh (-), child is Rh (+)

38
Q

ABO antibodies in infants are detected in serum:

A

3 to 6 months after birth

39
Q

Which cells agglutinate most strongly with Ulex europaeus lectin?

A

O

40
Q

If a patient has an A2 ABO type, which of the following statements is true?

A

The patient’s serum will react with A1 cells if anti-A1 is present

41
Q

Of the red cells listed, which has the most D antigen present?

A

D- - / D - -

42
Q

A trauma patient with type AB is seen at a rural hospital. The hospital only has 3 units of type AB RBCs. What blood type of RBCs can the patient receive as an alternative?

A

A, B, O

43
Q

If a person has the genetic makeup Hh, AO, LeLe, sese, what substance will be found in the secretions?

A

Lea SUBSTANCE

44
Q

Anti-E will react with which of the following cells?

A

R2R2

45
Q

Rh antibodies react best at what temperature (°C)?

A

37C

46
Q

Which of the following is the most common haplotype in the ASIAN population?

A

DCe

47
Q

If a patient who is R1R1 is transfused with RBCs that are Ror, which antibody is he most likely to produce?

A

ANTI-c

48
Q

Which of the following characteristics best describes Lewis antibodies?

A

IgM, naturally occurring, do not cause HDN

49
Q

Transformation to Leb phenotype after birth may be as follows:

A

Le(a–b–) to Le(a+b–) to Le(a+b+) to Le(a–b+)

50
Q

Transformation to Leb phenotype after birth may be as follows:

A

Le(a–b–) to Le(a+b–) to Le(a+b+) to Le(a–b+)

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