BB D-1 Flashcards
What type of serological testing does the blood bank technologist perform when determining the blood group of a patient?
PHENOTYPING
Which genotype(s) will give rise to the Bombay phenotype?
hh only
Which of the following describes the expression of most blood group antigens?
CODOMINANT
What blood type is not possible for an offspring of an AO and BO mating?
AB, A, B, O
A patient’s serum is incompatible with O cells. The patient RBCs give a negative reaction to anti-H lectin. What is the most likely cause of these results?
THE PATIENT MAY BE A BOMBAY
What antibodies are formed by a Bombay individual?
ANTI-A, ANTI-B, AND ANTI-H
Acquired B antigens have been found in
GROUP A PERSONS
Which typing results are most likely to occur when a patient has an acquired B antigen?
Anti-A 4+, anti-B 1+, A1 cells neg, B cells 4+
Which blood group has the LEAST amount of H antigen?
A1B
What should be done if all forward and reverse ABO results are negative?
Incubate at 22°C or 4°C to enhance weak expression
N-acetyl-D-galactosamine is the immunodominant carbohydrate that reacts with:
Dolichos biflorus
A stem cell transplant patient was retyped when she was transferred from another hospital. What is the most likely cause of the following results?
IMMUNODEFICIENCY
A complete Rh typing for antigens C, c, D, E, and e revealed negative results for C, D, and E. How is the individual designated?
Rh NEGATIVE
A patient tests positive for weak D but also appears to have anti-D in his serum. What may be the problem?
A D mosaic may make antibodies to missing antigen parts
What does the genotype —/— represent in the Rh system
Rh NULL
What techniques are necessary for weak D testing?
37°C incubation + indirect antiglobulin test
Which of the following sugars must be present on a precursor substance for A and B antigenic activity to be expressed?
L-FUCOSE
Lectins are useful in determining the cause of abnormal reactions in blood bank serology. These lectins are frequently labeled as anti-H, anti-A1 etc. The nature of these lectins is explained by which of the following?
A plant substance that chemically reacts with certain RBC antigens
If a patient has the Rh genotype DCe/DCe and receives a unit of red blood cells from a DCe/dce individual, what Rh antibody might the patient develop?
ANTI-c
Which of the blood group systems is associated with antibodies that are generally IgM?
LEWIS
Associated with Group 1 ABO discrepancies
Subgroups of A or B
An antigen present on most D-positive and all C-positive RBCs:
G
From the following ABO mating, what are the probabilities of the ABO PHENOTYPES of potential offspring? Mother: Group O; Father: Group B (heterozygous).
50% B, 50% O
Rh antibodies are predominantly
IgG
Rh immune globulin provides ____ protection against fetal D antigen.
PASSIVE
If an Rh negative woman recently delivered an Rh positive baby and the Kleihauer-Betke test result is 5%, how many vials of Rh Ig should be administered?
9
The glass surface of an Rh viewbox should be _____ C.
BETWEEN 45 and 50C
Anti-c can be formed by persons with the genotype
R1R1
The results of a Kleihauer-Betke stain indicate a feto-maternal hemorrhage of 35 mL of whole blood. How many vials of Rh immune globulin would be required?
2
ABH substances would be found in the saliva of a group B secretor:
B and H
The immunogenicity of the common Rh antigens may be described from greatest to least:
D>c>E>C>e
An individual with genes A, H, Se and lele has which of the following phenotypes?
AH, Le (a-b-)
The antigen system closely associated phenotypically with Rh is known as:
LW
“O” secretor person would demonstrate what substance/s in his saliva:
H
Which of the following is NOT true about the anti-A and anti-B?
They are well-developed at birth
What chain is formed when the terminal galactose on the ABH precursor substance is attached to the N-acetylglucosamine in beta 1, 4 linkage?
Type 2 precursor chain
Rh-HDN occurs in what type of mother and child
Mother is Rh (-), child is Rh (+)
ABO antibodies in infants are detected in serum:
3 to 6 months after birth
Which cells agglutinate most strongly with Ulex europaeus lectin?
O
If a patient has an A2 ABO type, which of the following statements is true?
The patient’s serum will react with A1 cells if anti-A1 is present
Of the red cells listed, which has the most D antigen present?
D- - / D - -
A trauma patient with type AB is seen at a rural hospital. The hospital only has 3 units of type AB RBCs. What blood type of RBCs can the patient receive as an alternative?
A, B, O
If a person has the genetic makeup Hh, AO, LeLe, sese, what substance will be found in the secretions?
Lea SUBSTANCE
Anti-E will react with which of the following cells?
R2R2
Rh antibodies react best at what temperature (°C)?
37C
Which of the following is the most common haplotype in the ASIAN population?
DCe
If a patient who is R1R1 is transfused with RBCs that are Ror, which antibody is he most likely to produce?
ANTI-c
Which of the following characteristics best describes Lewis antibodies?
IgM, naturally occurring, do not cause HDN
Transformation to Leb phenotype after birth may be as follows:
Le(a–b–) to Le(a+b–) to Le(a+b+) to Le(a–b+)
Transformation to Leb phenotype after birth may be as follows:
Le(a–b–) to Le(a+b–) to Le(a+b+) to Le(a–b+)
