BB Flashcards

1
Q

Single blood donation to multiple patients:

A
  • COMPONENT PREPARATION
  • RBCs, platelets, fresh-frozen plasma, cryoprecipitate, plasma derivatives
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2
Q

EQUIPMENT IN THE COMPONENT MANUFACTURING LABORATORY:
1. CENTRIFUGES
- spin a maximum of ___ at once
- ___; ___ can be changed based on ___

A. HARD SPIN
- depends on ___
B. SOFT SPIN
- not remove ___ out of ___

A
  • 6-12 units of WB
  • programmable speed (RPM), time settings, components
  • length / duration & speed
  • plasma, RBC
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3
Q

AABB-RECOMMENDED CENTRIFUGE CONDITIONS
Components Prepared - Centrifuge Conditions

RBCs + Plasma:
RBCs + Platelet-Rich Plasma:
Harvesting Platelets / Cryoprecipitate from Plasma:

A

RBCs + Plasma: 5,000 x g, 5 minutes
RBCs + Platelet-Rich Plasma: 2,000 x g, 3 minutes
Harvesting Platelets / Cryoprecipitate from Plasma: 5,000 x g, 7 minutes

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4
Q

EQUIPMENT IN COMPONENT MANUFACTURING LABORATORY:
2. PLASMA EXPRESSORS
- apply ___ to the ___
- blood components flow ___ by ___

A
  • pressure, blood bag
  • flow from one bag to another, integrated tubing system
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5
Q

EQUIPMENT IN COMPONENT MANUFACTURING LABORATORY:
3. TUBING SEALERS
- tubing that connects blood bags:

A

PVC (POLYVINYL CHLORIDE) - resistant to damage

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6
Q

EQUIPMENT IN COMPONENT MANUFACTURING LABORATORY:
4. STERILE CONNECTION DEVICES (SDCs)
- ___ connected via ___ w/o ___
- each piece of tubing is placed in a ___ and ___

A
  • 2 separate blood bags, PVC tubing, breaching the integrity of either container
  • channel, clamped
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7
Q

EQUIPMENT IN THE COMPONENT MANUFACTURING LABORATORY:
5. STORAGE DEVICES
- carefully selected and validated; ___
- temp must be ___, ___ at least ___
- ___ if ___

A
  • FDA-regulated storage temperatures
  • continuously monitored, recorded, EVERY 4 HOURS
  • alert, unacceptable temperature
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8
Q

EQUIPMENT IN THE COMPONENT MANUFACTURING LABORATORY:
6. QUADRUPLE BAG
- ___ depending on the ___

MOTHER BAG - ___ (___)
SATELLITE BAGS (___) - ___ —> ___ will be transferred ___

A
  • triple bags, component that will be produced
  • primary component (whole blood)
  • 2, expression, separate component, directly
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9
Q

BLOOD COMPONENTS:

A

OXYGEN-CARRYING PRODUCTS

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10
Q

THE WHOLE BLOOD AND ITS COMPONENTS:
WHOLE BLOOD
- ___
- ___ - ___

A
  • mother / primary component
  • unmodified - directly from the donor
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11
Q

WHOLE BLOOD
Indications:

A

Indications:
Active bleeding
Hemorrhagic shock
Exchange Transfusion
Both oxygen-carrying capacity and volume expansion required

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12
Q

WHOLE BLOOD
Shelf-life:
21 DAYS:
35 DAYS:
42 DAYS:

A

WHOLE BLOOD
Shelf-life:
21 DAYS: CPD, ACD, CP2D
35 DAYS: CPD-A1
42 DAYS: CPD-AS-1 (Adsol), AS/3 (Nutricel), AS-5 (Optisol)

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13
Q

WHOLE BLOOD
Shelf-life:
___: CPD, ACD, CP2D
___: CPD-A1
___: CPD-AS-1 (Adsol), AS/3 (Nutricel), AS-5 (Optisol)

A

21 DAYS: CPD, ACD, CP2D
35 DAYS: CPD-A1
42 DAYS: CPD-AS-1 (Adsol), AS/3 (Nutricel), AS-5 (Optisol)

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14
Q

WHOLE BLOOD
Characteristics:
* WBCs and Platelets - no longer viable after ____
* LABILE FACTORS (FACTORS ___ & ___) - significant ___ AFTER ___

A
  • 24 HOURS
  • V & VIII, decrease, 2 DAYS
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15
Q

WHOLE BLOOD
Storage Temp:

A

1-6 degC (monitored temp)

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16
Q

WHOLE BLOOD
Transport:

A

WET ICE w/ cloth & paper; do not put directly in ice

17
Q

WHOLE BLOOD
Immediate Effect of one unit:
Post-transfusion CBC:

A

ABOUT 30% INCREASE Hct PER 1 UNIT WB
AFTER 6 HOURS

18
Q

ASSOCIATED PROBLEMS AFTER WB TRANSFUSION

A
  1. Circulatory overload in patients that require only oxygen-carrying capacities in the RBC
    PRBC - anemia or oxygen-carrying capacity
    WB - both oxygen-carrying capacity and volume expansion; only if there is a shortage of component
  2. Not indicated to correct anemia for normal volemic patients - the additional volume of plasma is unnecessary and may cause volume-related complications
19
Q

CONTENTS:
PRBC -
LEUKODEPLETED RBCs -
WASHED RBCs -

A

CONTENTS:
PRBC - Hct should be 80% or less
LEUKODEPLETED RBCs - Residual WBCs
WASHED RBCs - Removal of plasma proteins, platelets, leukocytes and cellular debris

20
Q

STORAGE TEMP:
WHOLE BLOOD -
PRBC -
LEUKODEPLETED RBCs -
REJUVENATED RBCs -
WASHED RBCs -
FROZEN > THAWED > DEGLYCEROLIZED RBCs -

A

STORAGE TEMP:
WHOLE BLOOD - 1-6 degC
PRBC - 1-6 degC
LEUKODEPLETED RBCs - 1-6 degC
REJUVENATED RBCs - 1-6 degC
WASHED RBCs - 1-6 degC
FROZEN > THAWED > DEGLYCEROLIZED RBCs - 1-6 degC

21
Q

SHELF LIFE:
WHOLE BLOOD -
PRBC -
LEUKODEPLETED RBCs -
REJUVENATED RBCs -
WASHED RBCs -
FROZEN > THAWED > DEGLYCEROLIZED RBCs -

A

SHELF LIFE:
WHOLE BLOOD
21 days: CPD, ACD, CP2D
35 days: CPD-A1
42 days: CPD-AS-1 (Adsol), AS-3 (Nutricel), AS-5 (Optisol)

PRBC
Open System: Transfused within 24 hours; can be stored in refrigerator depending on the anticoagulant
Increased probability of product contamination; no integrally attached collection needles in the satellite bag
Closed System: Should NOT be exposed to air
If no PRBC → centrifuge WB to separate plasma and keep PRBC

LEUKODEPLETED RBCs
Closed System: depend on anticoagulant; same with other RBC components
Open System: 24 hours

REJUVENATED RBCs
Can be prepared 3 days after expiration of blood
Use of anticoagulant → New shelf life of rejuvenated RBC after addition of rejuvesol will be 24 HOURS

WASHED RBCs
Open System: valid for 24 hours

FROZEN > THAWED > DEGLYCEROLIZED RBCs
Frozen: 10 years
Deglycerolized: already gone thawing process; 24 hours