BB 1 Midterm 2 Flashcards
1
Q
ABO Phenotypes
A
A, B, O, AB
2
Q
B lectin
A
Bandeiraea Simplifiolia
3
Q
H lectin
A
Ulex Europaeus
4
Q
A1 lectin
A
Dolichos biflorus
5
Q
Mixed field (mf)
A
Observation of multiple cell populations in blood
6
Q
Phenotype
A
Blood group characteristics based on antigens
7
Q
Terminal sugar of B antigen
A
Galactose
8
Q
Terminal sugar of A antigen
A
N-acetylgalactoseamine
9
Q
Terminal sugar of H-antigen
A
Fucose
10
Q
H substance (most to least)
A
Order of abundance: O>A2>B>A2B>A1>A1B
11
Q
A frequency
A
45%
12
Q
B frequency
A
20%
13
Q
O frequency
A
45%
14
Q
AB frequency
A
5%
15
Q
ABO antigens
A
A, B, H
16
Q
Rh Antigens
A
D, C, c, E, e
17
Q
Rh disease link
A
Hydrops Fetalis (HDN)
18
Q
Rh: order of immunogenicity
A
D>c>E>C>e
19
Q
Anti-f
A
c and e on same haplotype
20
Q
R1 antigen
A
DCe
21
Q
R2 antigen
A
DcE
22
Q
R0 antigen
A
Dce
23
Q
Rz antigen
A
DCE
24
Q
r’ antigen
A
dCe
25
r'' antigen
dcE
26
r antigen
dce
27
ry
dCE
28
Rh positive
D antigen expressed
29
D frequency
85%
30
C frequency
70%
31
c frequency
80%
32
E frequency
30%
33
e frequency
98%
34
MNS Antigens
M, N, S, s, U
35
MNS disease link
Malaria falciparum and Renal disease
36
MNS chromosome
Chomosome 4
37
M frequency
85%
38
N frequency
70%
39
S frequency
50%
40
s frequency
90%
41
U frequency
100%
42
MNS nulls
Mk
43
MNS disequilibrium frequency
Ns>Ms>MS>NS
44
P/Glob Antigens
P1
45
P/Glob disease link
Paroxysmal cold hemoglobinuria and Spontaneous abortions
46
P1 phenotype
P1, P, Pk antigens
47
P2 phenotype
P, Pk antigens
48
p phenotype
Null (no antiens)
49
P1k phenotype
P1, Pk
50
P2k phenotype
Pk
51
P2 antibody
Anti-P1
52
p (null) antibody
Anti-PP1Pk
53
P1K antibody
Anti-P
54
P2k antibody
Anti-P1 and Anti P2
55
P/Glob chromosome location
Chromosome 22
56
P1 frequency
80%
57
P2 frequency
100%
58
P frequency
100%
59
Kell Antigens
K, k, Kpa, Kpb, Jsa, Jsb
60
Kell null
K null
61
Kell chromosome
chromosome 7
62
K frequency
9%
63
k frequency
100%
64
Kpa frequency
0%
65
Kpb frequency
100%
66
Jsa frequency
1%
67
Jsb frequency
100%
68
Kell, MNS, Lutheran
DTT destroys what system
69
Lewis Antigens
Lea, Leb
70
Lewis expression determines
Secretor Status
71
Lewis Chromosome
Chromosome 19
72
Lea frequency
20%
73
Leb frequency
70%
74
Duffy Antigens
Fya, Fyb, Fy3/Fy5
75
Duffy disease linkage
Malaria vivax
76
Duffy chromosome
Chromosome 1
77
Duffy Fy(a-b-) disease correlation
P. Vivax resistant
78
Fya frequency
60%
79
Fyb frequency
100%
80
Fy3/FY5 frequency
100%
81
Fy (a-b-) incidence
Common in west africa
82
Kidd Antigens
Jka, Jkb, JK3
83
Kidd chromosome
Chromosome 18
84
Kidd null
Jk(a-b-) or Jk3-
85
Jka frequency
75%
86
Jkb frequency
75%
87
JK3 frequency
100%
88
Kidd clinical significance
Delayed hemolytic TRXN
89
Kidd System Marked effect
Marked Dosage effect
90
Lutheran Antigens
Lua, Lub
91
Abnormal Result common in Lutheran
Mixed Field common in
92
Lutheran Chromosome
Chromosome 19
93
Lutheran nulls
In (Ln) dominant, Recessive, X-linked
94
Lua frequency
5%
95
Lub frequency
99%
96
Lutheran disease correlation
Stickiness and Tumor Metastasis
97
Antigens with significant Racial Frequency differences
S, C, c, P1, Jsa, Fya, Fyb, Jkb
98
Neutralization principle
Uses substance to bind antibody is the principle of
99
Neutralization substance of P1
Hydatid cyst fluid
100
Neutralization substance of Lewis
Saliva
101
Neutralization substane of Chido/Rodgers
Serum (complement)
102
Neutralization substance of Sd3
Urine
103
Neutralization substance of I
Human Breast milk
104
Gerbich antigens
Ge 1-4
105
Gerbich presentation
Elliptocytes
106
Diego Antigens
Dia/Dib and Wra/Wrb
107
Diego incident
Dia high in S.American indians
108
Colton Antigens
Coa/Cob, Co3 (null
109
Dombrock antigens
Doa/Dob, Gya (null)
110
Dombrock frequency
caucasian frequency matches duffy
111
Cartwright antigens
Yta/Ytb
112
Cartwright frequency
Ytb more common in Israelis
113
Chido/Rodgers
Ch 1-6, Rg 1-3
114
Chido/Rodgers action
Complement (C4) absorbed
115
Cromer antigens
Cra, Tca/Tcb/Tcc, Dra
116
Cromer frequencies
Cra high in black pop, Dra high in Japanese
117
Knops antigens
Kna, Knb, McCa/McCb, Sla/Vil
118
Indian antigens
Ina, Inb
119
Indian prevalency
Prevalent in Iran and india
120
Landsteiner Weiner antigens
Lwa/Lwb
121
Scianna antigens
Sc1/Sc2, Sc3 (null)
122
Xga antigens
Xga CD99
123
Xga presentation
More common in females (x-linked)
124
Ralph antigen
MER2
125
Ralph antigen location
Platelets
126
OK antigens
OKa
127
OK disease link
Receptor for plasmodium falciparum
128
JMH antigen
JMH
129
HLA antigen
Bga, Bgb, Bgc
130
Warm Reacting antigens
Kell, Duffy, Kidd, Lub, some P, some M
131
Cold reacting antibodies
ABO, Rh, MNS some, Some P, Lewis antigens Lua
132
Antibody groups that fix complement
ABO, Kiss, Lewis, P, Duffy/Lutheran (some)
133
Antibody groups that don't fix complement
Rh, Kell, MNS, P1/p
134
Enzymes enhance these antigen
Rh, Kell, Kidd, Lewis, P (enzymes)
135
Enzymes destroy these antigens
Duffy and MNS (Enzymes)
136
IgM Antibodies
Cold Antibodies
137
IgG Antibodies
Warm Antibodies
138
Use of LISS
Reduce Zeta Potential
139
Use of PEG
Remove water volume
140
Use of Albumin
Increase collisions
141
Use of Bromelin
Reduce steric hindrance
142
Use of Polybrene
Polymer nonspecific binding
143
Gel
Precipitation through Polyacrylamide gel matrix
144
Solid Phase
Adherence of antibody to RBC antigen on solid surface
145
Alleles
SNPs, alternate form of gene
146
Null
Absence of antigenic expression
147
Identifiable complement protein on the outside of red cell
C3B
148
ABO stimulated
IgG
149
ABO Naturally occurring
IgM
150
Kx (decreased kell)
Acanthocytes
151
K null
McLeod syndrome
152
Most common antibody
Anti-K
153
Sickle cell pt phenotyping
K antigen phenotyping
154
Lutheran is critical for ___ to ___
adhesion to laminin
155
Patient plasma with patient cells at IAT
Autocontrol
156
Clinically significant
Causes TRXN or HDN
