Basis of Embryology Flashcards
what is measured to find out about GH secretion
IGF-1
what cells secrete prolactin
lactotroph cells of the anterior pituitary
when is dynamic pituitary testing done
before imaging
what is the stimulation test for cortisol used to test for adrenal insufficiency i.e. Addison’s
synacthen test
what is the suppression test for cortisol used to test for adrenal excess i.e. Cushing’s
Screening test -
1mg overnight dexamethasone suppression test
Diagnostic test -
low dose dexamethasone suppression test
if ACTH is low where is the origin of the cause of Cushing’s likely to be and what should the next investigation be
adrenal
CT scan of adrenal glands
if ACTH is raised what could be causing the Cushing’s syndrome
Cushing’s disease (pituitary adenoma)
Ectopic ACTH
what indicates a pituitary source rather than ectopic
rise in cortisol and ACTH
how should a pituitary source be investigated
MRI of pituitary
what is MEN syndrome
Multiple Endocrine Neoplasia
- there are functional hormone producing tumours in multiple organs
what are features of MEN 1
autosomal dominant
MEN1 gene - 11q
- is a Classic tumour suppressor gene
what are features of MEN 2
autosomal dominant
RET gene - 10q
- is a classic photo oncogene gene
what are the common tumours in MEN 1
Parathyroid adenoma Pituitary adenoma Pancreatic islet cell tumours Gastrinoma Lipoma Angiofibroma
which type of MEN is more likely to run in the family
MEN 2
what is a common presenting complaint of MEN 1
signs/symptoms of hypercalcaemia
- due to pituitary tumour
