Basics of Neuropathology Flashcards
What kind of hydrocephalus?
Focal obstruction within ventricular system.
Noncommunicating
What kind of hydrocephalus?
Obstruction outside ventricular system
Enlargement of entire system
Communicating
What kind of hydrocephalus?
Dilation of ventricular system with increase of CSF due to volume loss of brain parenchyma
Hydrocephalus ex vacuo
What kind of herniation?
• Cingulate gyrus is displaced under the edge of falx
• Compression of anterior cerebral artery
Subfalcine herniation
What kind of herniation?
Medial aspect of temporal lobe compressed against free margin of tentorium
Uncal (transtentorial) herniation
Uncal herniation causes all of the following except: A. Pupillary dilation B. Impaired ocular movement C. Contralateral hemiparesis D. Duret hemorrhage E. Posterior cerebral artery compression
C. Ipsilaterlal hemiparesis
A, B due to CN3 compromised
What kind of herniation?
Displacement of cerebellar tonsils through foramen magnum
Tonsillar herniation
What kind of herniation?
Life-threatening b/c cause brain stem compression → compress vital respiratory and cardiac centers in medulla
Tonsillar herniation
Neurofibrillary tangles seen in
Alzheimer disease
Loss of substantia nigra seen in
Parkinson disease
Chronic gliosis seen in
Huntington’s disease
Most important histopathologic indicator of CNS
Marker of neuronal cell loss
Gliosis
Thick elongated brightly eosinophilic inclusions in astrocytic processes
Rosenthal fibers
Seen in low grade gliomas
Accumulation of intermediate fibers
T/F: Oligodendrocytes experience morphologic change in response to injury.
False. NO morphologic changes
