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BMS 4A > BASIC VIROLOGY > Flashcards

BASIC VIROLOGY Flashcards

1
Q

agen infeksi terkecil

A

virus

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2
Q

bagaimana keragaman asam nukleat virus

A

beragam dan bisa menginfeksi banyak sel

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3
Q

kondisi yang menghancurkan kestabilan virus

A
  1. pemanasan pd suhu 50-60 selama 30 menit
  2. radiasi, UV
  3. formaldehid yg bisa bereaksi dengan asam nukleat
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4
Q

kondisi yang menstabilkan virus

A
  1. garam

2. ph 5-9

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5
Q

apa peran garam dalam meningkatkan kestabilan virus

A

media transport virus

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6
Q

agen kemoterapi apa yang tidak mempan untuk virus

A

antibiotik, antifungi, antibakteri

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7
Q

parasit intrasel : bakteri

A

tidak

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8
Q

parasit intrasel : chlamydia/ricketsia

A

ya

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9
Q

parasit intrasel : virus

A

ya

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10
Q

membran plasma : bakteri

A

ya

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11
Q

membran plasma : chlamydia/ricketsia

A

ya

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12
Q

membran plasma : virus

A

tidak

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13
Q

binary fission : bakteri

A

ya

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14
Q

binary fission : chlamydia/ricketsia

A

ya

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15
Q

binary fission : virus

A

tidak

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16
Q

pass through biological filter : bakteri

A

tidak

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17
Q

pass through biological filter : chlamydia/ricketsia

A

ya/tidak

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18
Q

pass through biological filter : virus

A

ya

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19
Q

ada DNA dan RNA : Bakteri

A

ya

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20
Q

ada DNA dan RNA : chlamydia/ricketsia

A

ya

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21
Q

ada DNA dan RNA : virus

A

tidak

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22
Q

ATP generating metabolism : bakteri

A

ya

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23
Q

ATP generating metabolism : chlamydia/ricketsia

A

ya/tidak

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24
Q

ATP generating metabolism : virus

A

tidak

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25
Q

ribosom : bakteri

A

ya

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26
Q

ribosom : chlamydia/ricketsia

A

ya

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27
Q

ribosom : virus

A

tidak

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28
Q

sensitivitas pada antibiotik : bakteri

A

ya

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29
Q

sensitivitas pada antibiotik : chlamydia/ricketsia

A

ya

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30
Q

sensitivitas pada antibiotik : virus

A

tidak

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31
Q

sensitivitas thd interferon : bakteri

A

tidak

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32
Q

sensitivitas thd interferon : chlamydia/ricketsia

A

tidak

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33
Q

sensitivitas thd interferon : virus

A

ya

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34
Q

3 bentuk dasar virus

A

heliks, polihedral, kompleks

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35
Q

viru yang kapsidnya berupa cangkang spiral diebut

A

heliks

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36
Q

nukleokapsid =

A

nukleid acid core + kapsid

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37
Q

nukleid acid core + kapsid

A

nukleokapsid

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38
Q

virion =

A

nukleokapsid + envelope

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39
Q

docking glikoprotein HIV

A

gp120

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40
Q

transmembrane glikoprotein HIV

A

9p41

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41
Q

gp120 =

A

docking glikoprotein HIV

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42
Q

gp41 =

A

transmembrane glikoprotein HIV

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43
Q

kapsid :

A

cangkang protein yg membungkus nukleid acid core

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44
Q

bentuk DNA virus

A

ds, ss

sirkuler, linier, segmented

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45
Q

contoh virus dengan DNA segmented

A

orthomyxovirus

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46
Q

dimana letak kapsomer berada pada virus

A

kapsid

47
Q

siapa sj yg punya kapsomer

A

beberapa virus

48
Q

bahan penyusun kapsomer

A

polipeptida

49
Q

fungsi utama structural protein

A

mentransfer asam nukleat virus ke host cell

50
Q

bagaimana kondisi structural protein dalam sel

A

aktif/inaktif

51
Q

apakah semua virus punya amplop

A

tidak

52
Q

darimana asal amplop virus

A

lipid dr membran host cell

53
Q

bagaimana wujud glikoprotein

A

spikes/tonjolan pd amplop

54
Q

perubahan pada struktur apa pd virus yang menyebabkan sulitnya vakinasi

A

glikoprotein

55
Q

pertanyaan yang masih terngiang terkait evolusi virus

A
  1. bagaimana asam nukleat punya kemampuan infeksius?

2. evolusi apa yang dialami virus?

56
Q

famili virus diakhiri dengan

A

-viridae

57
Q

genus virus diakhiri dengan

A

-virus

58
Q

klasifikasi virus dilakukan brdasar

A
  1. morfologi
  2. asam nukleat
  3. tissue tropism
59
Q

klasifikasi berdasar moroflogi didasarkan pd

A

ada tidaknya amplop

60
Q

virus DNA

A
  1. adenovirus
  2. herpesvirus
  3. parvovirus
  4. poxvirus
  5. hepadnavirus
  6. papovirus
61
Q

virus yang tropismenya di usus

A

rotavirus

62
Q

virus yang tropismenya di hati

A

hepatitis virus

63
Q

virus yang tropismenya di RT

A

influenzavirus

64
Q

virus yang onkogenik

A

HPV

65
Q

virus yang tropismenya di saraf

A

poliovirus

66
Q

virus yang tropismenya di kulit

A

herpesvirus

67
Q

apa yg dimaksud virus defective

A

virus yang tidak punya gen fungional untuk replikasinya

68
Q

contoh defective virus

A

HDV

69
Q

bahan yang dibutuhkan HDV untuk bisa replikasi

A

hbsag

70
Q

metode isolasi, kultivasi dari virus apa saja

A
  1. kultur di hewan
  2. kultur di embryonated egg
  3. kultivasi di kultur sel
71
Q

hewan yg dipakai utk menanam virus

A

tikus, kelinci

72
Q

dalam kultur virus di hewan apa saja yang diamati

A

tanda gejala, infected tissue

73
Q

pertumbuhan virus di telur dicirikan

A
  1. kematian embrio
  2. discoloration chorioallantoic membrane
  3. adanya protein virus di telur
74
Q

dalam kultivasi di kultur sel medium yg dipakai?

A

cell line

75
Q

sumber cell heLa

A

sel primer yang berasal dr kanker

76
Q

sumber vero cell

A

sel dr ginjal kera

77
Q

apa yg diamati pd kultur cell virus

A

efek sitopatik

78
Q

efek sitopatik tdd

A

lisis sel dan tidak bisa bermultiplikai

79
Q

identifikasi virus scr kualitatif

A
  1. mengamati sel yang terinfeksi

2. mengamati ada/tidaknya inclusion bodies

80
Q

identifikasi virus cr kuantitatif

A
  1. metode fisika = mikroskop elektron

2. metode biologi = menentukan derajat kerusakan sel

81
Q

urutan tahap multiplikasi virus

A
  1. attachment
  2. penetration/engulfment
  3. uncoating
  4. ekspresi gen dan sintesis komponen viral
  5. morfogenesis dan release
82
Q

attachment virus terjadi antara

A

ligand (virus) dan reeptor sel

83
Q

apa yg menjadi kunci patogenisitas virus?

A

ada tidaknya reseptor sel

84
Q

apa yang menyebabkan tropisme?

A

perbedaan reseptor di sel tubuh kita

85
Q

dimanakan structural protein bekerja?

A

din penetration/engulfment

86
Q

enetration/engulfment terjadi melalui proses?

A
  1. endositosis diperantarai reseptor, membentuk endosom
  2. penetrasi langung partikel virus melintasi membran plasma
  3. fusi membran plasma dan amplop virus
87
Q

apa yang terjadi selama uncoating

A

nucleid acid core akan dilepas dr komponen luar virus

88
Q

bagaimana wujud dr genom virus

A

asam nukleat bebas/nukleokapsid

89
Q

kapan infektivitas viru menghilang

A

uncoating

90
Q

mengapa infektivitas virus bisa menghilang

A

dipisahkan dari protein struktural yang menunjang kelangsungan hidupnya

91
Q

setelah uncoating, kemana genom virus bergerak

A

sitool/nukleus

92
Q

apa yang terjadi pada genom virus agar bisa ditranslasi

A

harus diubah jd rnam

93
Q

contoh virus ukuran besar

A

herpesvirus, poxvirus

94
Q

virus yang besar ukurannya dependent thd inang dalam proses apa

A

multiplikasi

95
Q

virus yang besar ukurannya dependent thd inang dalam multiplikasi, konsekuensi?

A

proses virus besar lebih spesifik shg lebih mudah jd target antivirus

96
Q

assembly komponen virus menghasilkan apa

A

progeny virus

97
Q

pasca uncoating, kemana DNA virus bergerak

A

nukleus

98
Q

nama lain + rna strand

A

sense

99
Q

nama lain - rna strand

A

antisense

100
Q

enzim yang dibutuhkan - rna strand untuk berubah jd rnam

A

rna polimerasi

101
Q

ditinjau dr asam nukleatnya, siapakah viru yang melangsungkan proses yg lebih rumit?

A

virus DNA

102
Q

transduksi =

A

bakteriofag mentransfer materi genetik ke genom sel host

103
Q

bakteriofag mentransfer materi genetik ke genom sel host melalui proses

A

transduksi

104
Q

kegunaan bakteriofag

A

mempelajari epidemiologi host-parasite relationship

105
Q

siklus bakteriofag yang sifatnya laten

A

lisogenik

106
Q

prinsip viral diease

A
  1. viru masuk ke sel inang
  2. perlekatan ke susceptible cell
  3. multiplikasi genom virus
  4. interaksi dengan cell host = efek sitopatik
  5. penyakit
107
Q

apa yang terjadi pd infeksi virus yg akut?

A

multiplikasi virus meningkat cepat

108
Q

apa nyang terjadi pd infeksi virus laten

A

virus persisten didalam sel
dorman
hanya mengekspresikan sedikit genom

109
Q

sebutkan 2 mekanisme yg dijalankan oncogenic viral

A
  1. merubah regulasi cell growth

2. menghambat apoptosis

110
Q

cara langsung yg dilakukan oncogenic virus dalam merubah regulasi cell growth

A

menghasilkan protein fungsional for alteration

111
Q

cara tidak langsung yg dilakukan oncogenic virus dalam merubah regulasi cell growth

A

merubah ekspresi pre-existing celuller gene

112
Q

bagian virus yang bisa ada dalam bentuk aktif/inaktif

A

structural protein

113
Q

fenomena apa yg tampak spt gunung es

A

respons infeksi virus

BMS 4A (5 decks)

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