Basic of Kidney Disease Flashcards
What are the functions of the kidney?
Control of solutes and fluid status Blood pressure control Acid/base balance Drug metabolism/excretion Endocrine functions Metabolic waste
How can the waste excretion of the kidney be measured?
Urea
Creatinine
How can the endocrine function of the kidney be measured?
Vitamin D
EPO
PTH
How can the control of solutes and fluid status by the kidneys be measured?
U&Es
Urinalysis only tests albumin, not other proteins T/F?
True
How can proteinuria be quantified?
24 hour urine collection
Protein:creatinine ratio on morning spot sample
Albumin:creatinine ratio
What are the ideal qualities of a substance used to measure kidney function?
Freely filtered at glomerulus and not secreted or reabsorbed
Where does creatinine come form?
Breakdown product of muscle
What factors affect creatinine concentration in blood?
Kidney function
Plasma volume
Diet has a slight affect
When, other than kidney problems, will urea be elevated?
High dietary protein
GI bleed
Tissue breakdown
What is renal clearance?
The volume of plasma which can be cleared of a substance per unit of time
What factors are used in the MDRD. formula to calculate eGFR?
Plasma creatinine concentration
Age
Gender
Race
eGFR assumes stable renal function. T/F?
True
