Bartling... Flashcards
Role of Arachidonic acid and prostaglandins
inflammatory and pain mediator
Precursors of eicosanoids
Prostalgandins, leukotriens
First stage in converting arachidonic acid to prostaglandins
Cyclooxygenase isoforms (COX-1 COX-2)
COX-1 COX-2 expression
Cox1: constitutive
Cox2: in response to inflammatory mediators
COX role
stimulate inflammation, regulate blood flow to organs such as kindney, control ion transport, induce sleep
lypoxygenases
Arachidonic acid converted into leukotrienes
NO stimulates
guanylate cyclase
Phagocytosis activated by
PAMPS (pathogen-associated molecular patterns)
Iron transport is an example of
receptor mediated endocytosis
Clathrin coated vesicles are involved in
Receptor mediated endocytosis
Transcytosis
movement of receptors to a different membrane from the one in which it was endocytosed