Bartling... Flashcards

1
Q

Role of Arachidonic acid and prostaglandins

A

inflammatory and pain mediator

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2
Q

Precursors of eicosanoids

A

Prostalgandins, leukotriens

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3
Q

First stage in converting arachidonic acid to prostaglandins

A

Cyclooxygenase isoforms (COX-1 COX-2)

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4
Q

COX-1 COX-2 expression

A

Cox1: constitutive
Cox2: in response to inflammatory mediators

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5
Q

COX role

A

stimulate inflammation, regulate blood flow to organs such as kindney, control ion transport, induce sleep

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6
Q

lypoxygenases

A

Arachidonic acid converted into leukotrienes

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7
Q

NO stimulates

A

guanylate cyclase

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8
Q

Phagocytosis activated by

A

PAMPS (pathogen-associated molecular patterns)

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9
Q

Iron transport is an example of

A

receptor mediated endocytosis

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10
Q

Clathrin coated vesicles are involved in

A

Receptor mediated endocytosis

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11
Q

Transcytosis

A

movement of receptors to a different membrane from the one in which it was endocytosed

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