Barriers

Question 1

What is the physiological barrier to distribution?

Answer 1

Drugs are absorbed into the blood stream, the don’t have access to organs
There are barriers

Question 2

What are the barriers in the body

Answer 2

Blood brain barrier (BBB)

Dynamic interface that separates the CNS from the vascular system

Question 3

What is the role of the kidney?

Answer 3

Kidneys maintain the water and electrolytes balance in the body

Question 4

What is the kidney barrier?

Answer 4

To maintain the kidneys its achieved by blood filtration followed by reabsorption and secretion
Selective process
The body discriminates between compounds

Question 5

What is one of the important transporters and where is it found?

Answer 5

P-glycoproteins (P-gp) and its found in the brain

Question 6

What is the role of P-gp?

Answer 6

Transfer drug compounds out of the body

Question 7

What is the placental barrier and what is its role?

Answer 7

Barrier between mother and foetus

Ensures substances cannot simply transfer between

Question 8

Describe the structure of the placental barrier

Answer 8

Vey porous (small holes) and allows many chemical substances to cross