Barbiturates Flashcards

1
Q

Method of Action

A

Bind GABAa at allosteric site different to that of benzos and others (increase duration of opening)
Longer T1/2 than benzos with more hangover (not thiopental)

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2
Q

Thiopental

A

Ultra-short acting
Used for induction in rapid sequence intubation
Administered I.V.
30 seconds for effect
Lipid soluble and immediately enters CNS
5-10min duration due to redistribution into fat and skeletal muscle

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3
Q

Phenobarbital

A
Treat generalised and focal seizures
Administration is slow
Causes prolonged sedation
High risk of hypoventilation and hypotension
T1/2: 75-100 hours
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4
Q

Primidone

A

Phenobarbital is an active metabolite
Used to manage seizures
Used with propanolol to treat essential tremor

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5
Q

Side Effects

A
Hypotension
Respiratory depression
Coma
Always avoided in the elderly
Exacerbated by other CNS depressants
Tolerance and physical dependence 
Addiction
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6
Q

Pharmacokinetics

A

Metabolised by CYP450

Inducer of this system- increase metabolism of Warfarin and Statins

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