Antidepressants Flashcards
1
Q
Tricyclic Antidepressants
A
Imipramine (non-selective amine uptake inhibitor) Mood elevation for severe depression Delayed onset- 2 weeks Anxiolytic Eating disorders Chronic pain
2
Q
TCA Side Effects
A
Sympathomimetic Tremor Antimuscarinic Sedative Hypotension Cardiac depression Seizures
3
Q
SSRIs
A
Fluoxetine Non-sedative Sexual dysfunction Anxiety Insomnia Eating disorders
4
Q
SNRIs
A
Reboxetine
5
Q
Monoamine Oxidase Inhibitors
A
Phenelzine Drug/food interactions Insomnia Sedation Hypotension Seizures
6
Q
Reversible Inhibitors of MAO A
A
Moclobemide
7
Q
Serotonin Syndrome
A
Overdose or multiple drugs Hyperthermia Myoclonus Seizures Fluctuating mental state and vitals
8
Q
MOA
A
Delayed onset- 2 weeks due to
Downreg: postsynaptic beta adreno, 5-HT2
Presynaptic: alpha2, 5-HT1A
Upreg: postsynaptic alpha1
9
Q
SSNRIs
A
Desvenlafaxine
10
Q
Other Drugs
A
Bupropion- DA, NA, 5-HT uptake inhibitor
Mirtazapine- alpha2, 5-HT2 antagonist
Trazodone- 5-HT2 antagonist and SERT
Agomelatine- 5-HT2 antagonist and melatonin agonist
Vilazodone- SSRI and 5-HT1A partial agonist
11
Q
Lithium
A
Mood stabiliser
Slow onset
Anti-aggression
CNS,Renal,thyroid,cardiac toxicity
