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Neuropharm > Anticonvulsants > Flashcards

Anticonvulsants Flashcards

1
Q

Epilepsy

A

Recurrent abnormal electrical discharges in the brain

Recurrent seizures may cause brain damage

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2
Q

Primary Generalised Seizures

A 
Absence
Myoclonic
Tonic-Clonic
Tonic
Aionic
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3
Q

Acute Induction

A

Pentylenetrazol- GABAa blocker inducing absence

Maximal electroshock

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4
Q

Chronic Induction

A

Glutamate and Ach agonists-status epilepticus

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5
Q

Antiepileptics

A

Ideal: Block cause
Realistic: Control seizure by reducing neuronal excitation
Block excitation or enhance inhibition

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6
Q

GABA

A 
Phenobarbital- partial seizures
Benzodiazepines- positive modulation
Ganaxolone- delta sub-unit
Vigabatrin- inhibit GABA transaminase
Tiagabine- GAT1 inhibitor
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7
Q

Tonic-Clonic and Focal

A

Phenytoin- Na channel blocker
Carbamazepine-
Ataxia, diplopia, hirsutism, agranulocytosis, gingival hyperplasia

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8
Q

Adjunct Focal Seizure Therapy

A

Lacosamide
Pregabalin
Gabapentin
Levitiracem

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9
Q

Generalised Absence

A

Ethosuxamide

Valproic Acid

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Neuropharm (12 decks)

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