Barbiturates

Question 1

What is the duration of action of Thiopental

Answer 1

Ultra short-acting

Question 2

Which are the short acting Barbs?

Answer 2

Pentobarbital
Secobarbital
Amobarbital

Question 3

Is Phenobarbital long or short acting?

Answer 3

Long acting >8hrs-days

Question 4

MOA of Barbs?

Answer 4

Agonist effects at the GABAa receptor
–>At high concentrations directly activate GABA receptor to enhance chloride permeability
Also has allosteric modulations to the GABA receptor

Membrane effects
–>Nonsepcific neuronal depression at high doses

Question 5

What are the indications for taking a Barb?

Answer 5

Insomnia
Seizure management
Anxiety
Anesthesia
neonatal Hyperbilirubinemia

Question 6

What effects absorption of a Barb?

Answer 6

Its lipid solubility

Question 7

Can Barbs cross the BBB?

Answer 7

Yes

Question 8

How are Barbs excreted?

Answer 8

Excreted in Urine as an Anion

Question 9

What are some AEs of Barbs?

Answer 9

Hangovers
Hyperalgesia –>extremely sensitive to pain
CNS excitation (overly stimulated) –>especially in elderly)
Hypersensitivity (allergic rxns)
Respiratory & cardio effects
–>Hypotension or Hypothermia
–>Respiratory failure***

Question 10

What are some CI in Barbs?

Answer 10

1. Acute intermittent porphyria
   - -> leads to demylination
   - -> paralysis on CNS
2. Anyone taking CNS depressants

Question 11

Are Barbs potent inducers of CYP450?

Answer 11

Yes

Question 12

What effects do Bicarb have on someone who took Barbiturates?

Answer 12

its increases the excretion of Barbs

Question 13

Chloral hydrate?

Answer 13

Sedative/Hyptonic

Question 14

What is Temazepam used for?

Answer 14

Improves sleep maintenance

Question 15

What are the effects of Benzos on sleep?

Answer 15

Increases the total sleep time

May prevent transition from Lighter stage 2 sleep into deep sleep (Stage 3-4)