Bacterial Toxins- Lecture 10/7/21 Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

4 Steps for bacterial disease

A
  1. Encounter host
  2. Establish an infectious niche
  3. Multiply, cause tissue damage
  4. Spread to other tissues, hosts, or both
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Toxin

A

A protein that damages eukaryotic cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Endotoxins

A

Non-proteinaceous lipopolysaccharide of gram-negative bacteria, overreaction of host immune response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

C. Difficile toxin structure (4 domains)

A
  • Enzymatically active domain
  • Cysteine protease domain (auto cleaves)
  • Hydrophibic region
  • Receptor binding carbohydrates
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Mechanism of C. Difficile

A

Threads through once early endosome acidifies-> acts on Rho proteins (G protein) which causes cell death

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Botulism symptom

A

Clostridium Botulinum causes flaccid paralysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Botulism mechanism of action

A

Cleaves proteins involved in the real ease of Acetylcholine at synaptic cleft, can’t contract muscles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

A-B toxin

A

A unit is enzymatically active

B unit is cell binding, triggers RME

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Tetanus symptoms

A

Clostridium tentani causes spastic paralysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Tetanus mechanism of action

A

Same as botulism, but targets GABA in the CNS which causes overactive contraction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Cholera symptoms

A

A lot of diarrhea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Cholera mechanism of action

A

Secretes AB toxin that locks GI G protein in on position, decreasing Na+ absorption and increases Cl- secretion, leading to mass water secretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly