Bacterial Toxins Flashcards

1
Q

Key Facts

A
  • major non protein toxin = lipopolysacchride present in gram negative bacteria

endotoxins

  • part of the gram neg bacterium
  • released upon lysis of cell
  • lipopolysaccharide
  • non specific
  • heat stable
  • non enzymatic activity
  • systemic effect
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2
Q

Lipopolysaccharide (LPS)

A
  • O antigen displays great variation between species and strains
  • O antigen are key target for host immune defences
  • Loss of O antigen results in rough stains
  • Loss of O antigen results in partial loss of virulence
  • specific O antigens are thought to be involved in adhesion
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3
Q

Exotoxins

A
  • actively generated
  • released from the cell
  • protein
  • often specific to certain strains
  • highly antigenic
  • mainly enzymatic activity
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