Bacterial Meningitis -- Listeria

Question 1

Microbiological characteristics?

Answer 1

Gram + rod, facultative intracellular parasite

Question 2

What type of immunity needed to fight Listeria?

Answer 2

Cell-mediated

Question 3

In whom can it cause serious disease?

Answer 3

Immunocompromised, pregnant, infants

Question 4

Where does it colonize in humans?

Answer 4

Intestine, vagina

Question 5

What food does it grow in?

Answer 5

dairy, meat, raw veggies

Question 6

Can Listeria grow in refrigerator temps?

Answer 6

Yes

Question 7

What animal cells does Listeria invade?

Answer 7

Epithelial cells and macrophages

Question 8

Do macrophages need cytokine activation to kill listeria?

Answer 8

Yes

Question 9

How does Listeria get into non-phagocytic host cells?

Answer 9

Internalin binding to E-cadherin on cell surface

Question 10

How does Listeria get out of the phagolysosome?

Answer 10

Listeriolysin O

Question 11

How does Listeria move about in the cell?

Answer 11

Host F-Actin

Question 12

How does Listeria avoid exposure to humoral immunity?

Answer 12

Moves cell-to-cell