Bacterial Meningitis Flashcards
causative agents for meningitis in kids younger than 3 mos
enteric, GBS, Listerial
LEG
causative agents for meningitis in kids 3 mos to 2 years
H flu!!, N. meningitides, strep pneumo
causative agents for meningitis in kids 2 - 11 years
strep pneumo and N. meningitides
strep pneumo vaccine effective in young kids
13 capsule = prevnar
structure of N. meningitides
gram - kidney bean
4 main virulence factors for N. meningitides
pilli, capsule, LPS, antigenic phase varient for capsule
reservior for N. meningitides
nasopharynx of humans
endemic N. meningitides strains in US
B and C
epidemic N. meningitides straind
A and C
causes rash in meningococcal dz
endotoxin = lipooligiosaccharide
cause of death in meningococcemia
pulm insufficiency
treatment for acute N. meningitides dz and prophylaxis
acute = pen, cefotxime and ceftriaxone prophylaxis = cipro
diff between Manactra and Menomune
both vaccines for N. meningitides
Menomune id unconjugated and therefore has NO memory component
Manactra is conjugated to diptheria toxin = memory
what N. meningitides strain is NOT protected by vaccines
B
how is N. meningitides transmitted
saliva
structure of H flu
small gram - rod NON-motile
special growth medium for H flu
CAP (will not grow on BAP) bc needs factors X and V
reservoir for H flu
humans
distinguishing factor that allows certain strains of H flu to causes systemic dz
capsule = type b and f
dz caused by encapsulated vs non-encapsulated strains of H flu
encapsulated = meningitis, epiglottits, arthritis, cellulitis, osteo
non-encapsulated = otitis media, respiratory dz, conjunctivis
Vaccine for H flu?
yes, conjugated to diptheria toxin but only b
structure od listeria monocytogenes
club shaped gram + rod
listeria monocytogenes intracellular or extracelluar parasite
intracell
what cells do listeria infect
mucosal epithelial and non-immune macrophages/monocytes
source of listeria monocytogenes infections
Food–unpasteruized soft cheeses, hot dogs, and deli meat
emperic treatment for otherwise healthy indiv with suspected bacterial meningitis
3rd gen cephlasporin (ceftriaxone)
ampicillin (if listeria suspected)
vanc (if resistant S. pneumo suspected)
+/- dexamethisone
