Bacteria Causing Granulamatous Disease Flashcards
TUBERCULOSIS which part of nasal septum is involved
Anterior part of nasal septum and anterior end of inferior turbinate are the sites commonly involved
Pathology of tb
there is nodular infiltration followed later by ulceration and perforation of nasal septum in its cartilagi- nous part.
Diagnosis of tb
biopsy and special staining of sections for acid fast bacilli and culture of organisms.
Treatment for tb
antitubercular drugs.
LUPUS VULGARIS
low-grade tuberculous infection commonly affecting nasal vestibule or the skin of nose and face
Skin lesion in LUPUS VULGARIS
brown, gelatinous nodules called “apple-jelly” nodules. In the vestibule, it presents as chronic vestibulitis.
LUPUS VULGARIS the perforations may occur at ——-part of nasal septum
cartilagi- nous part of nasal septum
diagnosis LUPUS VULGARIS
It is difficult to isolate tubercle bacilli by culture, however, biopsy of the lesion is useful to make the diagnosis.
Treatment LUPUS VULGARIS
antitubercular drugs.
LEPROSY causative agent
Mycobacterium leprae
LEPROSY is very common in
tropics and is widely preva- lent in India.
The nose is involved as a part of leprosy systemic disease, more often in the
lepromatous than tuberculoid or dimorphous forms of disease.
Clinical features of leprosy
Infection starts in the anterior part of nasal septum and anterior end of inferior turbinate. Initially, there is exces- sive nasal discharge with red and swollen mucosa. Later, crusting and bleeding supervene. Nodular lesions on the septum may ulcerate and cause perforation. Late sequelae of disease are atrophic rhinitis, depression of bridge of nose and destruction of anterior nasal spine with retrusion of the columella
Diagnosis of leprosy
scrapings of nasal mucosa and biopsy. Acid-fast lepra bacilli can be seen in the foamy appearing histiocytes called lepra cells.
Treatment of leprosy
dapsone, rifampin and isoniazid. Recon- struction procedures are required when disease is inactive
