Background

Question 1

What is the incidence/prevalence of nasopharynx cancer?

Answer 1

86K cases with 55K deaths annually world-wide

Marked geographical variation with incidence rate of 0.5-2 per 100K in the US and Western Europe, however, in endemic regions it’s 25 per 100K

Estimated 3-4K deaths in the US annually

Question 2

What are the 5 yr survival of nasopharynx ca?

Answer 2

38% - 72% (Stage I-IV) per SEER data

Question 3

What are the typical demographics for nasopharynx ca?

Answer 3

Median age of 55, endemic to Southern China, common in N. Africa and Middle East

Question 4

Risk factors of nasopharynx ca?

Answer 4

Endemic regions, Male sex (RR 2-3), EBV, and preserved and smoked foods, smoking, alcohol

Question 5

What is the incidence/prevalence of sinonasal cancer?

Answer 5

Incidence/prevalence is 0.56 per 100K, estimated 2000 cases per year in the US annually, nasal cavity and maxillary sinus most common

Question 6

What are the 5 yr survival of sinonasal ca?

Answer 6

35% - 63% (Stage I-IV) per SEER data

Question 7

What are the typical demographics for sinonasal ca?

Answer 7

Median age of 50-60, higher incidence in Japan and South Africa

Question 8

Risk factors of sinonasal ca?

Answer 8

Male sex, environmental/occupational exposure (eg. wood dusts, glues, adhesives), smoking HPV, retinoblastoma