Baby - CC Flashcards
Bilirubin conversion factor mg/dL to umol/L
17.1
Creatinine conversion factor mg/dL to umol/L
88.4
Sodium, Potassium, Chloride conversion factor mEq/L to mmol/L
1
TP/Albumin/globulin g/dL to mg/L
10
Ig conversion factor from mg/dL to mg/L
10
Ig conversion factor from mg/dL to g/L
0.1
Thryoxine ug/dL to nmol/L
12.9
BUN conversion factor from mg/dL to mmol/L
0.357
BUN to Urea
2.14
Urea to BUN
0.467
Normal BUN: Creatinine ratio
10-20:1
Creatinine clearance
Indirect method used to asses the glomerular filtration functioning capabilities of the kidneys
Creatinine
Index of overall renal function
B2 microglobulin
Appears in the urine when reabsorption is incomplete because of proximal tubular damage, as in acute kidney injury
Assay for urea that is inexpensive but lacks specificity
Colorimetric, diacetyl
Assay for urea that measures ammonia formation
Enzymatic
Simple nonspecific method for creatinine
Colorimetric, endpoint
Assay for creatinine which is rapid and with increased specificity
Colorimetric: kinetic
Assay for creatinine that measures ammonia colorimetrically or with ion-selective
Enzymatic
Assay for uric acid, problems with turbidity
Colorimetric
Asssay for uric that needs special instrumentation and optical cells
Enzymatic: UV
Assay for uric acid, interference by reducing substances
Enzymatic: H2O2
A progressive and irreversible loss of renal function, results from several disease entities
Chronic renal failure; Progressive and irreversible
Least interference with analysis; Natural
Heparin
Heparin for most chemistry tests; common
Lithium heparin
Glucose is metabolized at a room temperature
7 mg/dL/hour
Glucose is metabolized at 4degC
2 mg/dL/hour
Hypoglycemia
Blood glucose level less then 50 mg/dL
OGTT
Patient should be ambulatory; fasting of 8 to 14 hours
Unrestricted diet of 150 grams CHO/day for 3 days prior to testing
Performed routinely to monitor glucose control
Glycosylated hemoglobin
Gestational diabetes patients develop diabetes
Within 5 to 10 years
Sodium concentration in patient with DM
Decreased due to polyuria
Cholesterol [NCEP Guideline for acceptable measurement error]
CV ≤ 3%
Triglycerides [NCEP Guidelines for acceptable measurement error]
CV ≤ 5%
LDLs, HDLc [NCEP Guidelines for acceptable measurement error]
CV ≤4%
Minor lipoproteins
IDL and Lp (a)
Major structural protein in HDL
Apo A1
Major structural protein in VLDL and LDL
Apo B100
Structural protein in chylomicrons
Apo B48
LDL cholesterol may be calculated from measurements of:
TC, TAG and HDL-c
Floating beta-lipoprotein
B-VLDL
Sinking pre-beta lipoprotein
Lp (a)
HDL cholesterol protective against heart disease
≥ 60mg/dL
HDL cholesterol major risk for heart disease
<40 mg/dL
Serum cholesterol: moderate risk>170 mg/dL, high risk >185 mg/dL
2-19 years old
Serum cholesterol: moderate risk>200 mg/dL, high risk >220 mg/dL
20-29
Serum cholesterol: moderate risk>220 mg/dL, high risk >240 mg/dL
30-39 years old
Serum cholesterol: moderate risk>240 mg/dL, high risk >260 mg/dL
40 and over
One-step, direct method for cholesterol
Libermann-Burchardt (L-B) procedure
Current reference method for cholesterol
Abell-Kendall method
PiSO
Potassium: Inside
Sodium: outside
Chloride
Counterion of sodium
Counterbalance of sodium
Routinely measured electrolytes
Sodium, potassium, chloride and bicarbonate
Largest contribution to the osmolality value of serum
Sodium, chloride and bicarbonate
Osmolality of plasma
2 Na + Glucose (mg/dL) / 20 + BUN (mg/dL) / 3
Or
1.86 Na + glucose/18 + BUN/2.8 + 9
Osmolal gap
Difference between the measured osmolality and calculated osmolality
Indirectly indicates the presence of osmotically active substances other than Na+, urea, or glucose, such as ethanol, methanol, ethylene glycol, lactate, or B-hydroxybutyrate
Anion
Na - (Cl + HCO3)
NV: 7-16 mmol/L
Anion gap
Na + K) - (Cl + HCO3
NV: 10-20 mmol/L
Anion gap exceeds 16 mmol/L
Indication of increased concentrations of the unmeasured anions (PO4 3-, SO4 2-, proteins ions
ADIC
Anion Decrease
Increase Cation
Decrease anion gaps of less than 10 mmol/L