B6.024 - Dermatopathology FLIP Prework Flashcards

1
Q

epidermal inflammatory diseases

A
  1. psoriasis
  2. eczema
  3. lupus erythematosus
  4. lichen planus
  5. erythema multiforme
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2
Q
A

psoriasis

Genetic/environmental etiology

4% pop

beefy red plaques with silver scale

scalp, elbowsm knees, sacrum

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3
Q
A
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4
Q

allergic skin diseases: eczemas

A

allergic contact eczema - potent exogenous allergen

atopic eczema - endogenous predisposition

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5
Q
A

allergic contact dermatitis

caused by contact with external allergen

poison ivy

nickel

balsam of peru

neomycin

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6
Q
A

atopic eczema

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7
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8
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9
Q
A

lupus erythematosus

Anti DNA Antibodies (ANA)

may affect any organ, butterfly malar rash, female>male, african american >

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10
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11
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12
Q
A

lichen planus

pruritic

purple

polygonal

papules

Wickam striae

symmetric distrubution

30-60 yo

hepatitis C, medication, contact allergen

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13
Q
A
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14
Q
A

erythema multiforme

acute eruption

HSV, mycoplasma

young adults

target lesions

self limited

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15
Q
A

acute eruption

HSV, mycoplasma

young adults

target lesions

self limited

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16
Q
A
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17
Q

blistering skin diseases

A
  1. pemphigus
  2. pemphigoid
  3. dermatitis herpetiformis
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18
Q
A

pemphigus vulgaris

40-60 yo

cutaneous erosions/oral ulcers

intact blisters are rare

Painful! Not itchy

Upper trunk and head

+nikolsky

Rx CTSD, immunosuppression

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19
Q
A

pemphigus vulgaris

40-60 yo

cutaneous erosions/oral ulcers

intact blisters are rare

Painful! Not itchy

Upper trunk and head

+nikolsky

Rx CTSD, immunosuppression

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20
Q
A
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21
Q
A

bullous pemphigoid

elderly pts

tense blisters and vesicles

lower abd, thighs, FAs

10-30% involve mucosa

severe pruritis

negativec nikolky sign

rx. topical / systemic CTSDs

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22
Q
A

Elderly, tense blisters and vesicles

lower abd, thighs, FAs

severe pruritis

negative nikolsky sign

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23
Q
A

elderly, tense blisters, vesicles

severe pruritis

negative niklosky sign

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24
Q
A
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25
Q
A

dermatitis herpetiformis

broad age range

grouped pruritic papules

knees, elbows, sacrum, nape of neck, scalp

associated with HLD DQ2, DQ8 CELIACS

dapsone, gluten free diet tx

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26
Q
A

dermatitis herpetiformis

broad age range

grouped pruritic papules

knees, elbows, sacrum, nape of neck, scalp

associated with HLD DQ2, DQ8 CELIACS

dapsone, gluten free diet tx

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27
Q
A

dermatitis herpetiformis

broad age range

grouped pruritic papules

knees, elbows, sacrum, nape of neck, scalp

associated with HLD DQ2, DQ8 CELIACS

dapsone, gluten free diet tx

28
Q

dermal/SQ inflammatory diseases

A
  1. acne
  2. rosacea
  3. urticaria
  4. leukocytoclastic vasculitis
  5. erythema nodosum
29
Q
A

acne vulgaris

85% of young adults

onset 9-11

papules, pustules, nodules, comedones

face/back/chest

increased sebum production

p. acnes lipase >> irritating fatty acids

follicular occlusion

Rx benzoyl peroxide, retinoid, ABX, OCP

30
Q
A

acne vulgaris

85% of young adults

9-11

papules, pustules, nodules, comedones

face/back/chest

increased sebum production

p acnes lipase >>> irritating fatty acids

follicular occlusion

rx. benzoyl peroxide, retinoid, ABX, OCP

31
Q
A
32
Q
A

rosacea

1-10% prevalence

fair skinned adults

30-50

redness and dilated blood vessels: nose, cheeks, forehead, chin

ocular: gritty sensation
phymatous: nodular thickening
papulopustular: like acne

rx avoid triggers, topical oral ABX

33
Q
A

rosacea

1-10% prevalence

fair skinned adults

30-50

redness and dilated blood vessels: nose, cheeks, forehead, chin

ocular: gritty sensation
phymatous: nodular thickening
papulopustular: like acne

rx avoid triggers, topical oral ABX

34
Q
A
35
Q
A

urticaria

AKA wheals, hives

1-5% prevalence

transiet plaques, often annular

pruritic and edematous

angioedema, mast cell degranulation

T1 HS

dermatographism

rx. antihistamines

36
Q
A

urticaria

AKA wheals, hives

1-5% prevalence

transiet plaques, often annular

pruritic and edematous

angioedema, mast cell degranulation

T1 HS

dermatographism

rx. antihistamines

37
Q
A

urticaria

AKA wheals, hives

1-5% prevalence

transiet plaques, often annular

pruritic and edematous

angioedema, mast cell degranulation

T1 HS

dermatographism

rx. antihistamines

38
Q
A
39
Q
A

leukocytoclastic vasculitis

all ages, mainly adults

palpable purpura

lower extermities, pressure points, dependent areas

50% idiopathic

remainder associated with infections, drug reactions, autoimmune illnesses

T3HS immune complex deposits

rare systemic involvement

ALWAYS GET A UA

rx. supportive, colchicine

40
Q
A
41
Q
A

erythema nodosum

tender nodules, shins

young women

T4 HS delayed type

50% idiopathic

sarcoid, drugs, IBD, URI

rx. bed rest, NSAIDs

42
Q
A
43
Q

skin infections/infestations

A
  1. viral wart
  2. molluscum contagiosum
  3. impetigo
  4. tinea
  5. deep fungal
  6. insect bites
  7. scabies
44
Q
A

viral wart aka verruca vulgaris

very common, children/YA

keratotic papules

hands, feet, face

HPV

rx. cryo/surgery, topicals

45
Q
A
46
Q
A

koilocyte is a halo around the cell indicating HPV

47
Q
A

molluscum contagiosum

children, YA, HIV+

umbillicated papules

face, neck, axillae, trunk, thighs buttocks, genitals

MC virus (a pox virus)

direct transmission

Rx: cryo, curettage, topical imiquimod and others

48
Q
A

Molluscum contagiosum

MC virus

49
Q
A
50
Q
A

Impetigo

common in kids

face/extremities

erosions and vesicles

honey colored crusts

blitsters

s. aureus (95%0
s. pyogenes –> glomerulonephritis

topical ABX

51
Q
A

Impetigo

common in kids

face/extremities

erosions and vesicles

honey colored crusts

blitsters

s. aureus (95%0
s. pyogenes –> glomerulonephritis

topical ABX

52
Q
A
53
Q
A

tinea

mainly post pubertal

dermatophtes esp trichophytum rubrum

transmission by direct contact

annular plaques with pusutles, active border

scalp, foot, body, toenal

rx topical or systemic antifungals

54
Q
A

tinea

mainly post pubertal

dermatophtes esp trichophytum rubrum

transmission by direct contact

annular plaques with pusutles, active border

scalp, foot, body, toenal

rx topical or systemic antifungals

55
Q
A

tinea

mainly post pubertal

dermatophtes esp trichophytum rubrum

transmission by direct contact

annular plaques with pusutles, active border

scalp, foot, body, toenal

rx topical or systemic antifungals

56
Q
A
57
Q
A
58
Q
A

deep fungal infection - aspergillosis

immunocompromised

papules, nodules, necrosis

occur at sites of trauma

may also disseminate from lung infection

aspergillus fumigatus

75-90% mortality in disseminated disease

Rx STAT systemic antifungals, surgical debridement if localized

59
Q
A
60
Q
A

insect bite reaction

excoriated papules

mosquitoes, fleas, ticks, chiggers, bedbugs, spiders

young, immunodeficient

rx remove ticks, topical antipruritics

61
Q
A
62
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A
63
Q
A

scabies

children, ya

finger webs, axillae, umbilicaus, areaolas

pruritic papules

itching worse at night

direct transmission

rx ivermectin pill or pemethrin cream

64
Q
A
65
Q
A

KOH preparation nastiest shit ive seen in my life