B5.013 Obesity Prework 2 Flashcards
rate of heritability of BMI
40-70%
obese person resting status differences with normal person
larger fat and lean mass higher resting energy expenditure higher CO higher BP greater pancreatic B cell mass higher insulin secretion (increases linearly with BMI)
secretions by white adipocytes
leptin
adiponectin
adipokines
brown adipocyte contents
UCP1
mitochondria
lipid droplets
what leads to a low grade systemic inflammatory state in persons with obesity
excessive secretion of proinflamamtory adipokines and macrophages within adipose tissue
psych effects of obesity
increased prevalence of mood, anxiety, and other psych disorders
particularly in those w severe obesity
bidirectional
how much weight loss is associated w clinically meaningful improvements in obesity related metabolic risk factors and coexisting disorders
5-10%
5% helps with insulin sensitivity
how many counseling sessions are helpful for weight loss
> 14 in a 6 month period
diet changes for weight loss
1200-1500 per day for women
1500-1800 per day for men
macronutrients based on patients preference
physical activity recs for weight loss
150 min per week of aerobic activity
behavior helpful for weight loss
daily monitoring of food intake and physical activity
weekly weight monitoring
pharmacotherapy recommendations
as an adjunct to reduced calorie diet and increased activity
BMI > 30
OR
BMI 27-29 with one coexisting condition
most widely used weight loss med
phentermine
bariatric surgery indications
class 3 obesity, BMI 35-39 with one coexisting condition other interventions not working
gastric banding
least invasive and safest
least weight loss
