B3- Infection And Response Flashcards

1
Q

What are pathogens?

A

Pathogens at microorganisms that enter the body and cause disease. They cause communicable diseases and can be spread. Both plants and animals can be infected by pathogens.

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2
Q

What are bacteria?

A

Bacteria are very small cells which can reproduce rapidly inside your body. They cause illness by providing toxins that damage your cells and tissues.

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3
Q

What are Viruses?

A

Viruses are not cells but like bacteria they can rapidly reproduce inside your body. They live inside your cells and replicate themselves using the cell’s machinery to produce many copies of themselves. The cell will usually then burst releasing the new viruses. The cell damage is what causes the illness.

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4
Q

What are protists?

A

There are multiple variations of protists but they’re all eukaryotes and most of them are single celled. Some protists are parasites.

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5
Q

What are parasites?

A

Parasites live on or inside other organisms and can cause them damage. They are often transferred to the organism b the vector which doesn’t get the disease itself.

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6
Q

What are fungi?

A

Some fungi are single celled. Others have a body which is made up of hyphae These hyphae can grow and penetrate human skin and the surface of plants causing diseases. The hyphae can produce spores which can spread to other plants and animals.

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7
Q

How can pathogens be spread?

A

Water- Some pathogens can be picked up by drinking or bathing in dirty water. E.g. cholera

Air- Pathogens can be carried in the air and can be breathed in. Some airborne pathogens are carried in the air in droplets when someone coughs or sneezes. E.g. the influenza virus that causes flu

Direct contact- Some pathogens can be picked up by touching contaminated surfaces including the skin. E.g. athlete’s foot which is spread by touching the same thing as the infected person

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8
Q

Explain what measles is

A

Measles is a viral disease which is spread by the droplets from an infected person’s cough or sneeze. People with measles develop a red skin rash and will develop a fever. Measles can be very serious or even fatal. For example measles can sometimes lead to pneumonia (lung infection) or a brain infection called encephalitis. Most people are vaccinated against measles when they’re very young.

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9
Q

Explain what HIV is

A

HIV is a viral virus spread by sexual contact or by exchanging bodily fluids such as blood. This can happen if people share needles when taking drugs. HIV initially causes flu like symptoms for a few weeks. Usually a person doesn’t then experience any symptoms for several years. During this time it can be controlled with antiretroviral drugs which stop the virus replicating in the body. The virus attacks the immune cells and if the body’s immune system is badly damaged it can’t cope with other infections or cancers. At this stage the virus becomes known as late stage HIV infection or AIDS.

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10
Q

Explain what tobacco mosaic virus is

A

Tobacco mosaic virus is a viral virus that affects many species of plants. It causes a mosaic pattern on the leaves of the plants and parts of the leaves become discoloured. The discoloration means the plant can’t carry out photosynthesis as well so the virus affects growth.

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11
Q

Explain what Rose black spot is

A

Rose black spot is a fungal disease where fungus causes purple or black spots to develop on the leaves of rose plants. The leaves can turn yellow and fall off. This means that photosynthesis can’t happen and it will affect the plant’s growth. It spreads through the environment in water or by the wind. Gardeners can treat the disease using fungicides and by stripping the plant of it’s affected leaves. These leaves then need to be destroyed so that the fungus can’t spread to other rose plants.

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12
Q

Explain what malaria is

A

Malaria is caused by a protist. Part of the malarial protist’s life happens in a mosquito. The mosquitos are vectors and pick up the malarial protists when they feed on the infected animal, it infects by inserting the protist into the animal’s blood vessels. Malaria causes repeating episodes of fever and can be fatal. The spread of malaria can be reduced by stopping the mosquitos from breeding. People can be protected by using insecticides and mosquito nets.

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13
Q

Explain what salmonella is

A

Salmonella is a type of bacteria that causes food poisoning. It is a bacterial disease. Infected people can suffer from fever, stomach cramps, vomiting and diarrhoea. These symptoms are caused by the toxins the bacteria produce. You can get salmonella food poisoning by eating food that has been contaminated with salmonella bacteria. In the UK most poultry are vaccinated against salmonella. This is to control the spread of the disease

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14
Q

Explain what gonorrhoea is

A

Gonorrhoea is a sexually transmitted disease. It is a bacterial disease and STI’s are spread by sexual contact. A person with gonorrhoea will get pain when they urinate and a thick yellow discharge from the vagina or penis. Gonorrhoea was originally treated with an antibiotic called penicillin but this has become trickier now because strains of the bacteria have become resistant. To prevent the spread of gonorrhoea people can be treated with antibiotics and should use barrier methods of contraception such as condoms.

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15
Q

How can the spread of disease be reduced or prevented?

A

Being hygienic- using simple hygienic measures can prevent the spread of disease. For example washing your hands before preparing food

Destroying vectors- By getting rid of the organisms that spread disease you can prevent the disease from being passed on. Vectors that are insects can be killed using insecticides or by destroying the habitat so they can no longer breed.

Isolating infected individuals- If you isolate someone who has a communicable disease it prevents them from passing it on to anyone else.

Vaccination- Vaccinating people and animals against communicable diseases means that they can’t develop the infection and pass it on.

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16
Q

List some features of the body’s defence system

A

.The skin acts as a barrier to pathogens and kills them
. Hairs and mucus in the nose trap particles that could contain pathogens
. The trachea and bronchi secrete mucus to trap pathogens
. The trachea and bronchi are lined with cilia which waft mucus to the back of the throat where it can be swallowed
.The stomach produces hydrochloric acid which kills pathogens that make it far from the mouth

17
Q

How does the immune system attack pathogens using white blood cells?

A

If pathogens do not make it into your body, your immune system kicks in to destroy them. The most important part of your immune system is the white blood cells. They travel in the blood and crawl into every pat of the body, constantly patrolling for microbes. When they come across an invading microbe they have three lines of attack.

  1. Consuming them- White blood cells can engulf foreign cells and digest them in a process called phagocytosis
  2. Producing antibodies- Every invading pathogen has unique molecules called antigens on it’s surface. When some types of white blood cell come across a foreign antigen they will start to produce proteins called antibodies to lock onto the invading cells so they can be found and destroyed by other white blood cells. The antibodies produced are specific to that type of pathogen and won’t lock onto any others. Antibodies then produced rapidly and carried around the body to fid all similar bacteria or viruses. If the person is infected with the same pathogen again the white blood cells will rapidly produce the antibodies to kill it- the person is naturally immune to this pathogen and won’t get ill.
  3. Producing antitoxins to counteract the toxins produced by the invading bacteria
18
Q

What is vaccination and how does it protect from future infections?

A

When someone is infected with a new pathogen it takes the white blood cells time to deal with it and by that time the person is ill. Vaccinations involve injecting small amounts of dead or inactive pathogens. These carry antigens which cause your body to produce antibodies to attack them even though the pathogen is harmless. But if live pathogens of the same type appear after that, the white blood cells can rapidly produce mass produced antibodies to kill of the pathogen.

19
Q

Give some advantages of vaccination

A

Vaccines have helped control lots of communicable disease that were once common in the UK. Smallpox no longer exists and polio infections have fallen by 99%

Big outbreaks of disease called epidemics can be prevented if a large percentage of the population is vaccinated. This means there would be fewer people to pass the disease on. But if a significant number of people aren’t vaccinated, the disease can spread quickly through them and lots of people will be ill at the same time.

20
Q

Give some disadvantages of vaccination

A

Vaccines sometimes don’t work and don’t give you immunity

You can sometimes have a bad reaction to vaccine such as swelling or fevers but bad reactions are very rare.

21
Q

What do painkillers do?

A

Painkillers are drugs that relive pain. However, they don’t actually tackle the cause of the disease or kill pathogens. They just help with the symptoms. For example aspirin

Other drugs do a similar thing and reduce the symptoms without actually tackling the problem. For example cold medicine

22
Q

What do antibiotics do?

A

Antibiotics work very differently as they don’t kill the bacteria causing the problem without killing your own body cells. Different antibiotics kill different types of bacteria. For example penicillin. Antibiotics don’t destroy viruses they reproduce using body cells which makes it very difficult to develop dugs that destroy just the virus without killing the body’s cells. The use of antibiotics has greatly reduced the number of deaths from communicable diseases caused by bacteria.

23
Q

How can bacteria become resistant to antibiotics?

A

Bacteria can mutate and can cause them to resist an antibiotic. If someone has an infection some of the bacteria might be resistant to antibiotics. This means when the infection is treated only the non-resistant strains of bacteria will be killed. The individual resistant bacteria will survive and reproduce and the population of the resistant strain will increase. This resistant strain could cause a serious infection that couldn’t be treated by antibiotics. To slow down the rate of development of resistant strains it’s important for doctors not to over prescribe antibiotics. It is also important that you finish the whole course of antibiotics.

24
Q

Explain how many drugs originally came from plants

A

Plants produce a variety of chemicals to defend themselves against pests and pathogens. Some of the chemicals can be used as drugs to treat human diseases or relieve symptoms. A lot of current medicines were discovered by studying plants used in traditional cures. For example aspirin is used as a painkiller and to lower fever. It was developed from willow. Some drugs were extracted from microorganisms such as penicillin was discovered from mould. These days drugs are made on a large scale in he pharmaceutical industry.

25
Q

Explain the first stage of drug testing

A

In preclinical testing, drugs are tested on human cells and tissues in the lab. However you can’t use human cells and tissues to test drugs that effect whole or multiple blood systems.

26
Q

Explain the second stage of drug testing

A

The next step in preclinical testing is to test the drug on live animals. This is to test efficacy and to find out about its toxicity and to find the best dosage. The law in the UK states a new drug must be tested on two different life mammals. Some people think it’s cruel but others believe it’s the safest way to make sure a drug isn’t harmful before giving it to humans.

27
Q

Explain the third stage of drug testing

A

If the drug passes the test on animals then it’s tested on human volunteers in a clinical trial. First the drug is tested on healthy volunteers. This is to make sure it doesn’t have any harmful side effects when the body is working normally. At the start of the trial, a very low dose of the drug is given and this is gradually increased.

If the results of the tests on healthy volunteers are good, the drugs can be tested on people suffering from the illness. The optimum dose is found and this is the dose of the drug that is the most effective and has few side effects.

To test how well the drug works, patients are randomly put into two groups. One is given the new drug and the other is given a placebo. This is so the drug can see the actual difference the drug makes and it allows for the placebo effect.

Clinical trials are blind so the patient in the study doesn’t know whether they’re getting the drug or placebo. In fact they’re often double blind as neither the patient or the doctor knows until the results have been gathered .This is so the doctors monotoning the patients and analysing the results aren’t subconsciously influenced by their knowledge.

The results of drug testing and drug trials aren’t published until they’ve been through peer review. This helps to prevent false claims.

28
Q

What is a placebo?

A

A placebo is a substance like the drug being tested but doesn’t do anything.