B16 Homeostasis Flashcards
What is homeostasis
The maintenance of a stable internal environment
Why is homeostasis important
For cells to function normally and for optimum enzyme activity for metabolic reactions
What happens when body temperature is too high
- enzymes vibrate too much due to higher kinetic energy
- this breaks the hydrogen bonds that hold them in their 3D shape
- shape of the enzymes active site is altered so ES complexes can’t form
- rate metabolic reactions slow down
What happens if blood pH is too high/ low
- hydrogen bonds holding enzymes in their 3D shape are broken
-shape of enzymes active site is altered
- enzyme denatures
- metabolic reactions slow down
What happens if blood glucose conc is too high
- the water potential of blood is greatly reduced to a point where water molecules diffuse out of the cells into the blood via osmosis
- cells shrivel up and die
How do homeostatic systems work
Receptors detect when a level is too high or too low
Info is communicated via the nervous system or hormonal system
Reaches the effectors which counteract the change and restores the level
What is negative feedback
Restores systems to their original level by reversing a change in the body
Why is having multiple negative feedback mechanisms useful
You can actively increase or decrease a level so it returns to normal
Gives more control
Faster response
What is a positive feedback mechanism
Amplifies a detected change
Which organ controls the blood glucose concentration
Pancreas
Insulin is secreted from
Beta cells in islets of Langerhans
Glucagon is secreted from
Alpha cells in islets of Langerhans
Insulin
Lowers blood glucose conc
Glucagon
Increases blood glucose conc
How does insulin lower blood glucose conc
5 things
Binds to specific receptors on liver and muscle cells and increases their permeability of glucose so glucose can more easily diffuse into cells
This causes more carrier proteins to move to the cell membrane
Stimulates glucose -> amino acids/fats/lipids
Increases the rate of respiration
Stimulates glycogenesis
Explain how the formation of glycogen in liver cells leads to a lowering of blood glucose conc
Glucose conc in cells creates a glucose conc gradient
Glucose leaves the blood via facilitated diffusion
How does glucagon work
Binds to specific receptors on liver cells
Stimulates gluconeogenesis and glycogenolysis by activating enzymes from the second messenger model
Decreases the rate of respiration
Where is adrenaline released from
Adrenal glands
How does adrenaline work
Stimulates glycogenolysis
Secretion of glucagon
Inhibition of insulin
How does the 2nd messenger model work
1) 1st messenger binds to receptors on liver cell
2) This activates adenylyl cyclase
3) This stimulates the conversion of ATP -> cAMP
4) cAMP activates protein kinase A which activates a cascade of reactions that break down glycogen to glucose
What happens in type 1 diabetes
The immune system attacks the Beta cells in the islets of Langerhans so they can’t secrete insulin
What is the main issue for people with type 1 diabetes
Hyperglycaemia as after eating the blood glucose level rises and stays high
How can type 1 diabetes be treated
Insulin therapy
Eating regularly
Controlling simple carbohydrates intake
What happens in type 2 diabetes
When Beta cells don’t produce enough insulin OR when the body’s cells don’t respond properly to insulin