B thala Flashcards
1
Q
HbF
HbA
HbA2
A
HbF - High
HbA - Absent
HbA2 -normal
2
Q
MCV / MCHC/ MHC
A
Microcytic Hypochromia
3
Q
Pathology
A
Excess a globin from mutation in B globin
Hb Precipitates = extravascular/intra haemolysis
Hb Precipitates in RBC precursors - ineffective erythropoiesis
Anaemia forms
Expansion of BM –>bone problems
Iron Absorption increases - ironoverload
4
Q
Treatment
A
splenectomy
Iron Chelation = deferoxamine
Ab against infection –>Klebsiella –> Norflaxacin
5
Q
Drug For Klebsiella
A
Norflaxacin
6
Q
Iron Chelation
A
Deferoxamine