B P10 C91 Cardiovascular Disease in Women

Question 1

True or False

An abnormal stress test in symptomatic women may still be consistent with IHD that is non-obstructive

Answer 1

True

Question 2

Identify trials that included women demonstrating the role of other imaging modalities

In women, a positive CCTA (vs. negative CCTA) was more predictive of events than a positive stress test (vs. a negative stress test)

Answer 2

PROMISE trial

Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE)

Question 3

Identify the trial

CCTA imaging was associated with a significant reduction in nonfatal MI and deaths for coronary heart disease at 5 years, when compared with standard of care in those presenting with stable chest pain

Answer 3

SCOT-HEART
Scottish Computed Tomography of the Heart) trial

Question 4

Sex specific risk factors

Early menarche (occurring at or before the age of ____ years) and late onset menarche (>_____ years) have both been shown to increase risk for adverse cardiovascular outcomes including myocardial infarction, stroke, and HF hospitalizations.

Answer 4

12 years
15 years

Question 5

ASCVD risk enhancers for women - give 4

Answer 5

Hypertension in pregnancy
Premature menopause (<40 years old)
Chonic imflammatory disorders such as RA, SLE, scleroderma
Breast cancer (plus effects of chemo such as anthracycline, trastuzumab)

Question 6

Noncoronary causes mimicking MINOCA

Answer 6

Supply demand mismatch
Takotsubo cardiomyopathy
Cardiomyopathies
Myocarditis

Question 7

Coronary causes of MINOCA

Answer 7

Plaque erosion, rupture
Coronary vasopasm
Microvascular dysfunction
Coronary embolism/thrombus
SCAD