B cell Flashcards
B cell negative selection occurs
bone marrow
B cell precursor rearranges its ig genes
in the bone marrow stromal cell
Immature B cell bound to self cell-surface is…
removed from the repertoire
Two ways to initiate B cell activation and humoral response
1) thymus depend
2) thymus indepedent tho not as efficent
which T cell activates the B cell
CD4 Helpter T cell
First signal
delivered by antigen via BCR
Second signal delivered by
1) thymus dependent > helper T cell
2) extensive crosslinking of surface igM
inefficent method of activation
thymus independent
T cells can only recognize small…presented in the MHC pocket of the antigen presenting cell
peptide
MHC II is loaded from material captured in the…
phaglysosome
The antigen recognized by BCR does NOT have to be the ……it presents to CD4 helper T cell
doesn’t have to be the same antigen recognized, can present something different
B cell captures molecular complexes/pathogen into its….via its…..
B cells use their BCR to capture antigen into their phagolysosome
What does B cell use to capture its antigen
BCR
BCR can recognize the external viral coat antigen but after digestion, the ……is presented to the T cell
internal viral antigen
hence forth the antigen recognized by B cell isn’t necessairly the same antigen it presents to CD4 t cell’
After B cell presents the antigen peptide to T helper cell, the T helper cell…..
releases cytokines to active the B cell, and the activated B cell PRODUCES AB against the viral coat protein
BCR can recognize……and…..unlike T cells which only recognize….
NON-peptides and peptides
Peptides for T cells only