Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Urology > B/1. Groups of antineoplastic drugs in urology > Flashcards

B/1. Groups of antineoplastic drugs in urology Flashcards

1
Q

Renal tumors - whats the first choice of treatment

A

1st choice is surgery (Not sensitive to chemotherapy)
pharmacologic therapy usually only if metastatic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

when is pharmacologic therapy used in renal tumors

A

usually only if metastatic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

pharmacological therapy of renal tumors

A
  • Immunotherapy: INF-alpha2, IL-2 (severe toxicity, used previously)
  • Chemotherapy: drugs targeting angiogenesis pathways
    *Tyrosine kinase inhibitors : VEGFR (sorafenib, sunitinib, axitinib, pazopanib)
    *mTOR inhibitors (everolimus, temsirolimus)
  • Bisphosphonates: in bone metastases
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

mTOR inhibitors

A

everolimus, temsirolimus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Tyrosine kinase inhibitors- VEGFR

A

(sorafenib, sunitinib, axitinib, pazopanib)
Targeted therapy : VEGF blocking drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

when are bisphosphonates used in renal tumors

A

in bone metastases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Renal pelvis or ureteric tumors- 1st choice of treatment

A

1st choice is surgery,
pharmacologic therapy usually only if metastatic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

localized disease Renal pelvis or ureteric tumors-
treatment and why is it used

A

first choice is surgery, if metastatic then:
* adjuvant therapy to reduce risk of recurrence
* Immunotherapy: bacillus Calmette-Guerin (BCG) -> intravesical
* Chemotherapy: mitomycin C (alkylating antibiotic)- pts w/low risk

same as for Non-muscle invasive/superficial Bladder tumors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Advanced and metastatic disease Renal pelvis or ureteric tumors -
what is the treatment? which is better and why?

A
  • urothelial cancer therapy should always be cisplatinum-based
    (alkylating agents)
    *Gemcitabin/cisplatin protocol is the most widely used
  • MVAC (MTX, vinblastine, adriamycin/doxorubicin, cisplatin): good response rates, but higher toxicity
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Non-muscle invasive/superficial Bladder tumors treatment

A
  • used as adjuvant therapy to reduce risk of recurrence
  • Immunotherapy: BCG instillation
  • Chemotherapy: mitomycin C, epirubicin, doxorubicin

SAME for localized disease Renal pelvis or ureteric tumor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Muscle-invasive Bladder tumors treatment

A
  • Neo-adjuvant (for operable stages T2-T4a)
  • Adjuvant (in locally advanced or LN+ states): cisplatin-based combination chemotherapy
  • M-VAC : Methotrexate, Vinblastine, Adriamycin, Cisplatin
  • Bone metastases: bisphosphonates, denosumab (RANKL inhibitor)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Testicular tumors stage 2-4 treatment

A
  • stage II-IV should use cisplatin-based chemotherapy
  • Chemotherapy if vascular or lymphatic invasion:
    -BEP: Bleomycin, Cisplatin 1st line, Etoposide
    -PVB: Bleomycin,Cisplatin, Vinblastine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

testicular tumor metastasis to ?

A

lung, bones, liver, and brain

the Paraaortic, retroperitoneal, supradiaphramatic lymph nodes

the chest
pelvis
the base of the neck.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Penile tumors treatment

A
  • adjuvant or neoadjuvant (for fixed inguinal LNs)
  • Suggested for advanced disease
    MTX
    Vincristine
    bleomyxin
    Cisplatin
    docetaxel
    5-FU
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Prostate tumors treatment in advanced disease

A
  • Hormonal therapy in advanced cases
  • Chemical castration with LHRH analogues or antagonists, which might be followed by hormone manipulation w/ antiandrogens
  • If castrate-resistance: novel antiandrogens (abiraterone acetate, enzalutamide), docetaxel
  • Bone metastases: bisphosphonates, denosumab (RANKL inhibitor), calcium and vitD supplementation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

bone metastasis of prostate tumor - treatment

A

Bone metastases: bisphosphonates(alendronate), denosumab (RANKL inhibitor), calcium and vitD supplementation

17
Q

castrate-resistance prostate tumors treatment

A

novel antiandrogens (abiraterone acetate, enzalutamide),
docetaxel (1st line)

18
Q

Chemical castration in prostate tumor which drugs used

A
  • LHRH analogues or antagonists
  • LHRH agonist (depot inj.): Leuprolide, Goserelin, Triptorelin
    *LHRH antagonist: degarelix
  • be followed by hormone manipulation w/ Antiandrogens (po): Flutamide
19
Q

Testicular cancer when is chemo used

A

Chemotherapy if vascular or lymphatic invasion
- BEP: Bleomycin, Etoposide, Cisplatin 1st line
- PVB: Cisplatin, Vinblastine, Bleomycin

Urology (30 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions