A/24. Pediatric urology Flashcards

1
Q

what do you have to keep in mind when treating a child with urological illness?

A
  • symptoms are often non specific
  • pediatrics urology doesnt simply mean surgery
  • treatment of a child has an impact on patient’s life for decades
  • management is only provided in specialised centers
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2
Q

what do you know about prenatal diagnostics?

A
  • Prenatal US diagnosis on pediatric urology is enormous!
  • A significant proportion of congenital disorders are
    detected in utero
  • a great number of these benefit from early diagnosis and prevention of secondary complications
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3
Q

pediatric urologial common symptoms?

A
  • Abdominal pain
    -Abdominal distension
  • loss of appetite
  • vomiting
  • anemia
  • failure to thrive (dystrophy, atrophy)
  • Pyuria with/without fever
  • Hematuria
  • Dysfunctional voiding, enuresis, incontinence
  • Abdominal mass
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4
Q

abdominal pain in <6 years vs above 6 yrs

A

< 6yrs: localized pain around the umbilicus
>6yrs: can specify affected site

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5
Q

what is the etiology of abdominal pain in pediatric urology?

A

UTI
ureteropelvic junction (UPJ) obstruction
ureterovesical stenosis
constipation
nephrolithiasis
renal tumor
spermatic cord torsion

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6
Q

how do you diagnose the abdominal symptoms?

A

physical examination
urinalysis
abdominal US
serum chemistry
retrograde voiding
cysto.urethrography
and radioisotope studies

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7
Q

Pyuria with/without fever in pediatric urology

-if febrile should be treated —–
- Underlying urological abnormalities
-UTI in newborn

A
  • Febrile UTIs should be treated acutely
    (since severe pyelonephritis–> renal scarring)

-investogate underlying urological abnormalities:
-> UPJ-obstruction
->VUR
->ureterocele
->neurogenic bladder

  • UTI in newborn is an emergency (can rapidly progress to urosepsis with fatal consiquences)
  • UTI may be present without pyuria, and pyuria may be present without UTI
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8
Q

hematuria in pediatric urology..
-microscopic Vs macroscopic

A

microscopic: often occurs in children, and may be benign
macroscopic:
->UTI
->urethral prolapse
-> trauma
->coagulation problem
->nephrolithiasis
->wilm’s tumor
->acute GN
->UPJ-obstruction
->hemorrhagic cystitis
->foreign body

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9
Q

Is cystoscopy indicated in case of hematuria?

A

yes.
since bleeding commonly originates from upper urinary tract

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10
Q

describe Dysfunctional voiding, enuresis, incontinence in pediatric urology…

-illness varies from —-
- primary goal is to

A

-Illnesses vary from minor changes to serious bladder damages
->minor: lazy bladder
->serious: neurogenic bladder or fibrosis of bladder wall (hinmann’s synd)

  • Primary goal is to differentiate benign from harmful lesions
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11
Q

what is the etiology of dysfunctional voiding, enuresis, incontinence in pediatric urology?

A
  • constipation
  • phimosis
  • meatal stenosis
  • previous urethral surgery
  • hinman’s synd (non-neurogenic neurogenic bladder= functional bladder outlet obstruction in the absence of neurologic deficits.)
  • ectopic ureter opening into vulva (girls)
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12
Q

what is the etiology behind abdominal mass in pediatric urology?

A
  • Majority originate in genitourinary organs
    1. large hydronephrosis
    2. extremely filled urinary bladder
    3. wilm’s tumor (nephroblastoma)
    4. retroperitoneal masses that push on kidney
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13
Q

list the Obstructive uropathies in pediatrics urology

A
  • Ureteroplevic junction (UPJ) obstruction
  • Obstructive megaureter
  • Ureterocele
  • infravesical obstruction -> post. urethral valves
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14
Q

UPJ obstruction is the most common —–
gender

A
  • UreteroPelvic Junction obstruction
  • Most common site of obstruction
  • Epidemiology: boys > girls
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15
Q

symp. of UPJ obstruction?

A
  • abdominal/flank pain
  • UTI
  • hematuria
  • abdominal masses
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16
Q

how do you diagnose UPJ obstruction?

A
  • prenatal US
  • diuretic renography (dynamic, noninvasive test which was developed to distinguish between the dilated non-obstructed and the dilated obstructed upper urinary tract)
  • IV urography
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17
Q

how do you treat UPJ obstruction?

A
  • conservative surgery:
    ->dismembered pyeloplasty
    -> Anderson and Hynes technique
  • Nephrectomy if poorly functioning kidney
    (<10% renal function)
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18
Q

what is the complication of UPJ obstruction?

A

hydronephrosis

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19
Q

what is the etiology of megaureter?

A
  • obstructive (ureterovesical stenosis)
  • non-obstructive (eg. VUR)
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20
Q

what are the symps of obstructive megaureter?

A

UTI
hematuria
flank pain

21
Q

how do you diagnose megaureter?

A

prenatal US

22
Q

how do you treat mega ureter?

A
  • ureteric reimplantation
    (methods of Cohen, Politano-Leadbetter, Jozsef Toth)
23
Q

what are the complications of mega ureter?

A

hydroureter
hydronephrosis

24
Q

describe ureterocele..

A
  • a cystic enlargement of the intravesical segment of the ureter, containing urine

In vast majority associated with complete duplication of the urinary tract -> obstructing the orifice of the ectopic (upper pole) ureter

25
Q

what are the symp. of uereterocele

A

UTI
prolapse of ureterocele
purulent drainage in diaper

26
Q

how do you diagnose ureterocele?

A

prenatal US

27
Q

how do you treat ureterocele?

A
  • Endoscopic ureterocele incision in newborns
  • Partial nephrectomy (upper pole heminephrectomy) due to hydronephrosis
28
Q

complications of ureterocele

A
  • Dilatation of ureter and hydronephrosis
  • Obstruction of internal meatus of the urethra, and the other ureteral orifice(s) as well
29
Q

describe infraurethral obstruction (post. urethral valves)

A

an obstructive membrane in the posterior male urethra

30
Q

what is the Treatment of infraurethral obstruction

A
  • Prenatally: intrauterin intervention attempt
  • Postnatally: valve ablation and sometimes early urinary diversion
31
Q

what are the complications of infravesical obstruction

A
  • congenital urethral obstruction: urinary tract above the obst. level is subject to abnormally high intraluminal pressure
    -> damage to post. urethra, bladder, ureters and kidney
    –> renal insufficiency
    -> oligohydraminos
    -> resp. distress and suffocation
32
Q

what is the prognosis of infravesical obstruction?

A

1/3 lethal
1/3 require renal transplantation
1/3 live with preserved kidneys

33
Q

what is VUR?
epidemiology

A

Vesicoureteral reflux

  • retrograde flow of urine from bladder to upper urinary tract
  • Epidemiology: 30-50 of pediatric pts. with UTI
34
Q

what is VUR etiology?

A
  • intrinsic anatomical deficiency of VU junction
  • dysfunctional VU obstruction
35
Q

how do you grade VUR?

A

grade I: reflux into ureter

grade II: reflux into kidney with maintenance of sharp angles of the fornix

grade III: reflux into kidney with mild loss of forniceal agnle (mild hydro-ureter)

grade IV: reflux involving papillary blunting and more severe loss of forniceal angle with moderate hydroureter and hydronephrosis

Grade V: reflux with loss of papillary impression and loss of forniceal angle, presenting with hydronephrosis and hydro-ureter

36
Q

how do you diagnose VUR?

A

contrast voiding cystourethrogram (VCUG)
US
direct isotope renography

37
Q

how do you treat VUR?

A
  • prolonged AB prophylaxis
  • correction of reflux via open/endoscopic surgery
    (high rate of immediate cure and small risk of complications)
38
Q

what are the complications of VUR?

A

pyelonephritis > renal scarring> renal insufficiency and HTN

39
Q

Genitourinary tumors

A
  • Wilm’s tumor (nephroblastoma)
  • Rhabdomyosarcoma
  • testicular tumors
40
Q

describe wilm’s tumors..

A
  • Arise anywhere in renal parenchyma
  • Expansive growth
41
Q

what is the Etiology of wilm’s tumors?

A

there is wilm’s tumore gene on chromosome 11p
deletetion/mutation of both alleles is needed

42
Q

common symps of wilm’s tumor?

A

abdominal mass
hematuria (25%)
fever (15%)
abdominal/flank pain (10%)
HTN
undescended testis

43
Q

how do you diagnose wilm’s tumors?

A

US: solid lesion, sometimes cystic areas
CT: shows exact extension and potential metastases

44
Q

how do you treat wilm’s tumors?

A

chemotherapy:
- actinomycin
- vincristine
- doxorubicin

surgery:
radical nephrectomy

45
Q

rhabdomyosarcoma in pediatric urology

-most commonly affects?
-pathology?

A

Most commonly affects:
-> prostate
-> bladder
-> paratestis

Pathology:
->embryonal (good survival rate)
-> alveolar
-> pleomorphic

46
Q

symps and treatment of Bladder and prostate in rhabdomyosarcoma

A

symps:
-urinary frequency
-hematuria
- urinary retention
- palpabale mass above symphysis

treatment:
-> surgery
-> chemo

47
Q

symps and treatment of paratesticular in rhabdomyosarcoma

A

vast majority is embryonal with good prognosis

symps:
-unilateral painless scrotal swelling or mass above the testis

treatment:
radical inguinal orchiectomy followed by chemo

48
Q

few words about testicular tumors in rhabdomyosarcoma…

A

Rare in childhood
see topic B10