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Pharmacology > Autonomic Receptor Pharmacology > Flashcards

Autonomic Receptor Pharmacology Flashcards

1
Q

Effects of sympathetic stimulation of the eye

A

A1 - Mydriasis (dilated pupil), B - Increased fluid inflow

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2
Q

Effects of sympathetic stimulation of the lung

A

B2 - Bronchorelaxation (increased airflow)

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3
Q

Effects of sympathetic stimulation of the heart

A

B1 more than B2 - Increased HR (SA node), Increased conduction (AV node), Increased contractility (Ventricle)

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4
Q

Effects of sympathetic stimulation of blood vessels

A

A1 - Constriction (increase BP), B2 - Dilation (skeletal muscle decrease BP)

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5
Q

Effects of sympathetic stimulation of stomach

A

A1,B2 - Decrease in motility, tone and secretion

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6
Q

Effects of sympathetic stimulation of intestine

A

A1,B2 - Decrease in motility and tone (constipation)

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7
Q

Effects of sympathetic stimulation of bladder

A

Relaxation (urinary hesitancy, retention)

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8
Q

Effects of sympathetic stimulation of glands

A

Some secretion

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9
Q

Effects of sympathetic stimulation of adrenal medulla

A

Epi release via nicotinic receptors

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10
Q

Effects of sympathetic stimulation of male sex organ

A

A1 - ejaculation

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11
Q

Effects of sympathetic stimulation of pancreas

A

A2 - Decreased secretion of insulin, B2 - Increased secretion of insulin

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12
Q

Effects of sympathetic stimulation of liver

A

A1, B2 - Gluconeogenesis, glycogenolysis

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13
Q

Effects of sympathetic stimulation of uterus (pregnant)

A

Relaxation

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14
Q

Effects of parasympathetic stimulation of eye

A

Mioisis (constricted pupil), accomodation for near vision, increase in fluid outflow

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15
Q

Effects of parasympathetic stimulation of lung

A

Bronchoconstriction

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16
Q

Effects of parasympathetic stimulation of heart

A

Decrease in HR and contractility

17
Q

Effects of parasympathetic stimulation of blood vessels

A

Dilation (not significant)

18
Q

Effects of parasympathetic stimulation of stomach

A

Increase in motility, tone and secretion

19
Q

Effects of parasympathetic stimulation of intestine

A

Increase in motility and tone (cramps, diarrhea)

20
Q

Effects of parasympathetic stimulation of bladder

A

Micturation

21
Q

Effects of parasympathetic stimulation of glands

A

Profuse secretion (sweating, salivation, etc)

22
Q

Effects of parasympathetic stimulation of adrenal medulla

A

None

23
Q

Effects of parasympathetic stimulation of male sex organ

A

Erection

24
Q

Effects of parasympathetic stimulation of pancreas

A

None

25
Q

Effects of parasympathetic stimulation of liver

A

None

26
Q

Effects of parasympathetic stimulation of uterus (pregnant)

A

Variable

27
Q

What type of receptor is present at the neuromuscular junction?

A

Nictotinic (Ach)

28
Q

What is the postganglionic receptor in the parasympathetic system?

A

Nictotinic (Ach)

29
Q

What is the target organ receptor in the parasympathetic system?

A

Muscarinic (Ach)

30
Q

What is the postganglionic receptor in the sympathetic nervous system?

A

Nicotinic (Ach)

31
Q

What is the target organ receptor in the sympathetic nervous system?

A

Adrenergic (receiving norepinephrine)

32
Q

What sympathetic target receptors are not adrenergic and what are they?

A

Sweat glands innervated by the sympathetic system use muscarinic receptors

33
Q

How does the muscarinic receptor work?

A

Stimulation of PLC, increase in IP3 and DAG, then NO-c-GMP (BVs) or decrease c-AMP (heart)

34
Q

What type of receptors are nicotinic receptors?

A

Ionotropic

35
Q

How do alpha1 receptors work?

A

Stimulation of phospholipases increase IP3, DAG, and Ca2+

36
Q

How do alpha2 receptors work?

A

Inhibition of adenylyl cyclase and decrease in c-AMP

37
Q

How do B1 and B2 adrenergic receptors work?

A

Stimulation of adenylyl cyclase and increase in c-AMP

Pharmacology (16 decks)

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