Adrenergic Antagonists

Question 1

Prazosin (give class, MoA, charge, and duration of action if known)

Answer 1

Alpha 1 blocker

Question 2

Tamsulosin (give class, MoA, charge, and duration of action if known)

Answer 2

Alpha 1 blocker

Question 3

Doxazosin (give class, MoA, charge, and duration of action if known)

Answer 3

Alpha 1 blocker

Question 4

Phentolamine (give class, MoA, charge, and duration of action if known)

Answer 4

Alpha 1 and Alpha 2 blocker, competitive, short acting

Question 5

Phenoxybenzamine (give class, MoA, charge, and duration of action if known)

Answer 5

Alpha 1 and Alpha 2 blocker, irreversible, long-acting

Question 6

Epinephrine reversal and its implication

Answer 6

Epi is not to be used with alpha blocker overdose because in this case epi will exert only its beta effects, which lead to decreased blood pressure (exacerbating the crisis caused by the alpha blocker overdose)

Question 7

Propanolol (give class, MoA, charge, and duration of action if known)

Answer 7

Beta 1 and 2 blocker, some CNS effects

Question 8

Timolol (give class, MoA, charge, and duration of action if known)

Answer 8

Beta 1 and 2 blocker, some CNS effects

Question 9

Nadolol (give class, MoA, charge, and duration of action if known)

Answer 9

Beta 1 and 2 blocker, less CNS effects than other B blockers

Question 10

Metoprolol (give class, MoA, charge, and duration of action if known)

Answer 10

Beta 1 blocker (aka carioselective beta blocker)

Question 11

Atenolol (give class, MoA, charge, and duration of action if known)

Answer 11

Beta 1 blocker (aka cardioselective beta blocker)

Question 12

Acebutolol (give class, MoA, charge, and duration of action if known)

Answer 12

Beta 1 blocker (aka cardioselective beta blocker)

Question 13

Labetalol (give class, MoA, charge, and duration of action if known)

Answer 13

Vasodilator beta blocker (blocks alpha and beta receptors)

Question 14

Pindolol (give class, MoA, charge, and duration of action if known)

Answer 14

Beta blocker with intrinsic sympathomimetic activity (partial agonist). If HR low, raises HR, if HR high, lowers HR

Question 15

Carteolol

Answer 15

Beta blocker with intrinsic sympathomimetic activity (partial agonist). If HR low, raises HR, if HR high, lowers HR

Question 16

Why should you not stop a beta blocker abruptly?

Answer 16

Because up-regulation of beta receptors occurs during beta blocker use

Question 17

What two classes of autonomic drugs are used to treat open angle glaucoma?

Answer 17

Muscarinic agonist (increases outflow) and beta blocker (reduces beta induced inflow)

Question 18

What is the generic name of flomax and what class of drug is it?

Answer 18

Tamsulosin, an alpha antagonist