Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

#Pharmacotherapeudics > Autonomic Pharm > Flashcards

Autonomic Pharm Flashcards

1
Q

Cholinergic focuses on the ____ NT. Includes: ______, _____, and ____

A

ACh

CNS, autonomic ns, and NMJ

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

action potential causes an influx of Ca2+, release of ACh is blocked by _______ and _____ causes an “invol” release

A

botulinum toxin

spider venom=release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

ACh binds ____ and ______ receptors

A

muscarinic and nicotinic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

nicotinic receptors are found _____ and ______

A

somatic motor endplates and autonomic ganglia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what are the 3 binding sites/areas for ACh to bind

A

pregang synapse of symp and parasymp (Nm, M1-3), parasymp post gang, and all somatic motor endplates (NM)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

M2 causes ____ heart rate

A

dec heart rate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

ACh causes _______ of the vascular beds. Via the M_ receptor

A

vasodilation

M3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

ACh causes _____ in cardiac rate, this is aka chronotropic

A

decrease

negative chronotropic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

ACh causes ____ in rate of conduction

A

decrease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

ACh causes _____ in force of contraction

A

decrease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

In the GI/Urinary syst ACh causes _____ in contractions/motility

A

increase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

ACh causes the stimulation of _________ of all glands parasympathetically

A

secretion inc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

ACh in the lungs causes ___________ and ___________

A

inc secretion

and bronchoconstriction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

ACh in the eye causes

A

miosis(pupil contracts) “mice eyes”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

carbachol and bethanechol have a longer action because

A

not very susceptible to AChE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

carbachol, methacholine, bethanechol, and pilocarpine all act on the __________ receptors

A

M1, M2, and M3

17
Q

Cevimeline binds to _________ receptors causing ______

A

muscarinic (ACh)

causes inc secretion of exocrine glands (used for xerostomia in sjogrens)

18
Q

muscarine acts almost exclusively at _______ receptors with no _______ action

A

acts at muscarinic

no nicotinic action

19
Q

Pilocarpine has a dom ______ action but causes anomolous effects on _____ and _____

A

muscarinic

anomolous CV and sweat gland efx

20
Q

________ is an antimuscarinic/ ACh antidote

A

Atropine

21
Q

what are the 3 contraindications for choline esters(ACh and Bethanechol)

A

asthma, hyperthyroid, coronary insuff

22
Q

what are the 6 irreversible indirect acting AChE inhibitors (cholinomimetics)

A 
echothiophate(for open angle glaucoma-crosses BBB)
Tabun
sarin
soman
parathion
malathion
23
Q

Isoflurophate is a _______ used to treat _____

A

indirect acting AChE inhibitors (cholinomimetic); used to treat open angle glaucoma

24
Q

What is DUMBBELSS for?

A

effects of excessive ACh at the muscarinic receptor

Diarrhea, Urination, Miosis, Bronchoconst/Bradycardia, Excitation, Lacrimation, Salivation/sweating

25
Q

What happens when you have excessive ACh at the nicotinic receptor?

A 
M: Mydriasis, musc twitch
T: tachycardia
W: weakness
tH: HTN, hyperglycemia
F: fasciulations
26
Q

what 2 drugs would you use to treat Sarin or soman (chem warfare) - - how do they work?

A

Atropine(antimusc)

Pralidoxime (cholinesterase reactivator)

27
Q

what is Methylscopolamine? indications?

A

antimusc/anticholinergic drug; for anti-ulcer

28
Q

anticholinergic is the same as _______

A

antimuscarinic

29
Q

Antimuscarinic drug toxicity sfx are the same as what drug?

A

atropine (don’t foget this includes Alt mental status)

30
Q

nicotinic response causes _____ or _____

A

musc depol or secretion of epinephrine by the adrenal medulla

31
Q

PTMA is

A

a nicotinic NMJ agonist (MTWtHF)

32
Q

DMPP works…

A

at the nicotinic ganglion

33
Q

the only nicotinic agonist drug is

A

nicotine

34
Q

________ and _________ are competative antagonists against ACh at ganglionic nicotinic receptor

A

Trimethphan
Mecamylamine
(not used because severe AR, maybe used in eye)

35
Q

_________, ______, and _______ are destroyed the fastest because they are eliminated by hydrolysis

A

Ata-, cistra-, and mivacurium

36
Q

____________ has the longest DOA and is “Depolarizing”=noncompetative, resistant to AChE

A

Succinylcholine

37
Q

_____________ can cause malignant hypothermia in those with the auto dom mutation

A

Succinylcholine

#Pharmacotherapeudics (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions