Autonomic Pharm Flashcards
2 common first line therapies for pregnancy
Methyldopa, Labetalol
4 Primary effects of ACh on CV system
Vasodilation, Dec HR, Dec AV Node conduction velocity, Dec force of contraction
a2 agonists are a useful adjuntive Rx, especially to block __
reflex tachycardia
A2 agonists are particularly useful in what type of patients
Diabetics and Asthmatics
a2 agonists have dose-dependent __
salt and water retention
A2 agonists that do not penetrate BBB, do not ___
decrease blood pressure
ACh acts on what receptors in vascular endothelial cells
M3 receptors
Action of a2 adrenergic autoreceptors
Limit release of NE from sympathetic nerves and Epi from adrenal chromaffin cells
Action of Clonidine
Binds auto-receptors (a2 agonist)
Action of Ephedrine
Mixed-actining sympathomimetic: direct agonist of a and b receptors
Action of Isopreterenol
Acts on beta in SM –> Vasodilation –> Reduction in Diastolic BP; Also increase HR
Action of Labetolol
A and B blocker
Action of Metyrosine
In tx of Pheochromocytoma, decreases excessive production of catecholamines by blocking tyrosine hydroxylase
Action of Phentolamine
Competitive antagonist at alpha1 and 2 receptors
Activation of alpha2 receptor:
Decreases production of cAMP –> Inhibition of further release of NE from Neuron (pre-synaptic)
Activation of beta 2 in skeletal muscle
Vasodilation
Activation of M2 Muscarinic Receptors –>
Gi/Go inhibit AC, decrease cAMP, activate inward rectifying K channels, inhibit v-gated Ca channels = Hyperpolarization/ inhibition
Activation of M3 Muscarinic Receptors –>
Gq/11, Activation of PLC, Increased IP3 and DAG, Increased Ca and PKC –> Depolarization and Excitation
Activation of vascular a2 adrenoreceptors leads to
vasoconstriction (when given locally, by rapid IV, or in very high oral doses)
Additional actions of Carvedilol, Acebutolol, Propranolol
Block fast Na+ channels (and thus rapid depolarization, phase 0) in non-nodal cardiomyocytes –> Decrease slope of phase 0, decrease amplitude of AP
Advantage of drugs with ISMA
Can stimulate resting heart to provide relief from bradycardia, but also inhibit stimulation by sympathetics
Adverse effects of Epi
Cerebral hemm; Vent Arrhythmias; Angina
Adverse effects of Ganglionic Blockers
Postural Hypotension, Tachycardia, Arrhythmias, etc.
AE’s of Ephedrine
Angina, Vent dysfunction/arrhythmias, Fatal arrythmias
AE’s of NE
Similar to Epi, but BP increase more prominent
AE’s of Phenoxybenzamine
Sinus tach, Nasal Congestion
AE’s of Phentolamine
Postural Hypotension, Reflex Tach that precipitates cardiac arrhythmias
After pretreat with alpha-blocker, what is effect of Epi
decrease in BP (vasodilation still intact (beta2), vasoconstriction blocked (alpha))
After pretreat with alpha-blocker, what is effect of NE
Very minimal rise in BP
After pretreat with beta-blocker, what is effect of Epi
Rise in BP (vasodilation blocked (beta2), vasocontriction intact (alpha))
After pretreat with beta-blocker, what is effect of isoproterenol
Elimination of drop in BP (beta only, mostly 2)
After pretreat with beta-blocker, what is effect of NE
Reletively normal rise in BP
Alfuzosin is used for
BPH (alpha-1a blocker)
Alpha blockers prevent ___ effect of NE
Vasoconstrictive (increase BP)
Alpha vs Beta blockers: prevent vasoconstrictive effect of NE
Just alpha
Alpha-1a receptors represent 70% of alpha receptors in
prostate
Alpha-1b and Alpha-1d receptors are in
vasculature
Alpha-blockers DTP have much higher affinity for which subtype
Alpha 1
Alpha: Post-synaptic, down-stream signaling
Alpha 1
Alpha: Pre-synaptic, auto-receptors
Alpha 2
Alpha1 receptor antagonism would prevent
reflex vasoconstrictive effect produced by beta blockers
Alpha2 agonist prodrug
methyldopa
Alpha2 agonists
Clonidine, Guanabenz, Guanfacine
At low conc., DA acts predominantly
on DA receptors in renal vasculature
Atropine with higher dose
Progressive tachycardia: Blockade of M2 receptors on SA nodal pacemaker cells (vagal tone antagonized)
Atropine with low dose
Blockade of presynaptic M1 receptors –> Increased ACh release
Autonomic control of resting heart is primarily
Parasympathetic
BB’s with __ tend to have less effect on TG’s and HDLs
ISMA OR Cardio-selectivity
BB’s with ___ tend to reduce total cholesterols and LDLs
BOTH ISMA AND Cardio-selectivity
BB’s with Membrane Stabilizing Activity
Carvedilol, Acebutolol, Propranolol
beta 2 receptor role in glucose regulation
Normally stimulate hepatic glycogen breakdown and pancreatic glucagon release (increase plasma glucose)
Block fast Na+ channels (and thus rapid depolarization, phase 0) in non-nodal cardiomyocytes –> Decrease slope of phase 0, decrease amplitude of AP
Additional actions of Carvedilol, Acebutolol, Propranolol
Blockade of alpha-1a in bladder neck and prostate can
improve urine flow and reduce symptomes of BPH
Cat. B a2 agonists
Methyldopa and Guanafacine
Cholinergic innervation in skeletal muscle
none
Clinical use of Dobutamine
Short-term tx of cardiac decompensation; After cardiac surgery, CHF, or Acute MI
Clinical use of Ephedrine
Hypotension
Clinical use of Phenylephrine
Control of Hypotension
CNS depression can occur with what type of BB drugs
Lipophilic
CNS effects of BB’s
Mental disorders, fatigue, vivid dreams
Concentration-dependent receptor effects of DA:
D1 –> B1 –> A
Correlation b/t serum levels of a2 agonists and duration of central effect
Poor
Difference b/t NE and Epi action
Epi also activates beta2 in skeletal muscle vessels –> Vasodilation and decline in BP
Direct cardiac effects of ACh are mediated primarily by
M2 receptors
Direct cardiac effects of ACh mediated primarily by M2 receptors
Activation of K-ACh channels; Inhibition of L-type Ca channels
Drugs that prevent Ca entry can cause
vasodilation of smooth muscle
Duration of Phenoxybenzamine vs Phentolamine
Phenoxy is longer duration
Effect of BB’s on Plasma Glucose
Hypoglycemia
Effect of beta-blockers on renin-angiotensin pathway
Blocks renin release from JGA of kidney
Effect of DA on CV system
Increased CO (contractility»_space; HR), D1 vasodilation; At high doses: Inc PVR and Renal vasoconstriction (alpha-agonism predominates)
Effect of Epi on Coronary BF
Increased (decreased systole duration)
Effect of Epi on Lungs
Inc Pulmonary pressures
Effect of Epi on Pulse Pressure
Inc in Systolic > Diastolic –> Increase in PP
Effect of Epi on Pulse Rate
Increase
Effect of Epi on TPR
Decrease
Effect of ganglionic blockade in Arterioles
Vasodilation; Increased Peripheral Blood Flow; Hypotension
Effect of ganglionic blockade in Veins
Dilation; Peripheral pooling of blood, Decreased venous return, Decreased cardiac output
Effect of ganglionic blockade on Heart
Tachycardia
Effect of Isoproterenol on Pulse
Increase
Effect of Isoproterenol on TPR
Decrease
Effect of M2 receptors on Peripheral Nerves
Inhibition via auto- and heter-receptors = Decreased ganglionic transmission
Effect of M2 receptors on SA node
Slowed, spontaneous depolarization; Hyperpolarization, decreased HR
Effect of M2 receptors on SM
Contraction
Effect of NE infusion
Predominantly activates a-adrenergic –> Raises BP –> Increased MAP and TPR –> Reflexive decrease in HR