04.08 - CV Misc 1 (Nichols) Flashcards
Transverse bands of hyper-contracted sarcomeres is called
Contraction banding
2 Malignant Vascular Neoplasms
Angiosarcomas, Hemangiopericytoma
A large facial telangiectasia in a child w mental deficiency may indicate
Presence of additional vascular malformations
Age and race of Prinzmetal angina
Japanese less than 50
Arterial ulcers, in contrast to venous, are
painful, punched out or stellate. Surrounding skin red and taut
Autosomal dominant disorder caused by mutations in TGF-beta signaling in endothelial cells
Hereditary Hemorrhagic Telangiectasia (Osler-Weber-Rendu)
Benign, very painful tumors arising from specialized SM cells of Glomus Bodies
Glomus Tumors
Capillary hemangiomas that manifest as rapidly growing red pedunculated lesions on skin, gingival, or oral mucosa
Pyogenic Granulomas
Cavernous Hemangiomas are one component of
von Hippel-Lindau Disease
CD31 is a marker for
Endothelial cells
Compared with Capillary Hemangiomas, Cavernous Hemangiomas are
More infiltrative, deeper, do not spontaneously regress
Coronary artery hyperreactivity is sometimes called
Cardiac Raynaud
Endothelial cell marker
CD31
Erythematous, scaling, and eczematous patches or plaques on LE’s
Stasis Dermatitis frequently presents with
Good test for DVT
D-Dimer
Hereditary Hemorrhagic Telangiectasia (Osler-Weber-Rendu) is caused by mutations in
TGF-beta signaling in endothelial cells
Hereditary Hemorrhagic Telangiectasia is aka
Osler-Weber-Rendu
Histologic Findings in acute cases of Ischemic Dilated CM (Takotsubo CM)
Contraction band necrosis
Homans Sign
Calf pain with forceful dorsiflexion of foot (not a good test)
How do the bac’s in Bacillary Angiomatosis cause proliferation
Induce host tissues to produce HIF-1alpha, which drives VEGF
How long does Prinzmetal angina last
5-15 minutes
How often do emboli occur from varicose veins
Rarely
Internal Hemangiomas are commonly found
in liver
Major difference between Benign and Malignant Vascular Tumors
Benign form more well-organized vessels
Migratory Thrombophlebitis - Trousseau Syndrome
When venous thrombi result from elaboration of procoagulant factors from malignant tumors and thrombos is diff vascular beds
Most common vascular ectasia
Nevus Flammeus
Most disabling sequelae of Varicose Veins
Edema, Stasis Dermatitis, Ulcerations
Most frequently involved location in Venous Stasis Dermatitis
Medial Ankle
Most important risk factor for DVT
Prolonged Immobilization (Venous Stasis)
Myocardial contraction band necrosis can be due to
Coronary Artery Vasospasm
Origin of Angiosarcomas
Endothelial Cells
Port Wine Stain lesions occuring in distribution of Trigeminal are associated with
Sturge-Weber Syndrome (Encephalotrigeminal Angiomatosis)
Prinzmetal Angina is associated with what EKG finding
ST Elevation
Spider Telangiectasiasa are most frequently associated with
Hyperestrogenic States
Spindle-shaped cells and blood with a light sprinkling of lymphocytes
Kaposi Sarcoma
Stasis Dermatitis frequently presents with
Erythematous, scaling, and eczematous patches or plaques on LE’s
SVC Syndrome is caused by
Neoplasms that compress or invade SVC
Syndrome of Myocardial Ischemia, MI, or SCD due to emotional stress
Takotsubo CM
Takotsubo CM
Syndrome of Myocardial Ischemia, MI, or SCD due to emotional stress
Telangiectasia is used to describe
Permanent Dilation of pre-existing small vessels that form a discrete red lesion
Top 3 associations for DVT
Cancer, Hospitalization, Surgery
Venous Stasis Ulcers are usually located on
Medial Ankle
What accounts for more than 90% of thrombophlebitis and phlebothrombosis
DVT
What drives proliferation of Kaposi Sarcoma
Viral homolog of CycD
What is Bacillary Angiomatosis
Vascular proliferation in immunocompromised hosts caused by gram-negative bacilli of Bartonella family
What leads to Chylous Ascites, Chylothorax, and Chylopericardium
Rupture of dilated lymphatics, typically following obstruction by an infiltrating tumor mass
What type of DVT are associated with clinically significant PE
Proximal (above popliteal)
When do you see contraction banding
Reperfusion of dead myocardium
When venous thrombi result from elaboration of procoagulant factors from malignant tumors and thrombos is diff vascular beds
Migratory Thrombophlebitis - Trousseau Syndrome
When will Acute MI take form of contraction band necrosis
Coronary Vasospasm; MI with Reperfusion
