Autonomic Nervous System drugs Flashcards
Differences between Affarent and Efferent neurons
Afferent neurons are sensory neurons that carry nerve impulses from sensory stimuli towards the central nervous system and brain, while efferent neurons are motor neurons that carry neural impulses away from the central nervous system and towards muscles to cause movement.
What is Cholinergic Agnonist
It Mimics the parasympathetic neurotransmitter which is the acetylcholine, where in the acetylcholine is synthesized, produce and release by the presynaptic nerve terminal
How does the medication work?
We have a theory called “Receptor Theory or Lock n key Theory it is a drugs that act through receptors by binding to the receptors to initiate a response or prevent a response. If the drugs is fit to the receptor then there would be an action but if the drug doesn’t fit to the receptor then it would not do any action.
What is the step 5 in Synaptic transmission
“Termination” after the binding and response, The step 5 will now terminate the neurotransmitter in 3 ways. The 5a will undergo in preoptic, 5b will undergo in enzymatic degradation and 5c will infuse away
Pharmacologic effect
The goals of autonomic drugs is not to treat an autonomic disorder but to correct the disorder organ through autonomic nerves
In SNS medication what is the use and receptor of Epinephrine
Epinephrine is commonly used in a cardiac arrest or asthmatic patient, It targets the A1, A2, B1, B2.
What is the Side effects of Andrenergic agnonist
- Tissue necrosis
- Tachycardia, palpitations, tremors, dizziness, increased blood pressure
- Urinary retention
What are the 4 drugs Autonomic Nervous System
Adrenergic agonist - It mimics the effects of SNS
Adrenergic antagonist - it stops or blocks the effect of SNS
Cholinergic agonist - it mimics the effects of PNS
Cholinergic antagonist - it blocks the effects of PNS
What is Orthostatic Hypotension
A sudden decrease of blood pressure from 20 mmHg in systolic blood pressure and 10mmHg in diastolic blood pressure
The receptor of Alpha 1 can be found in
(SNS)
- Blood vessels – Vasoconstriction, Increase blood pressure, Increase contractibility of the heart
- Eye – Mydriasis (pupil dilation)
- Bladder – Relaxation
- Prostate – Contraction
What are the therapeutic uses of Alpha 1
Alpha 1 can be used with the patient who experience Hypertension, Nasal congestion and dilation of pupils
What is the therapeutic use of Acetylcholine
The non-specific cholinergic effect, decrease CO, HR, and BP, increases GI activity
Facts about Parasympathetic Nervous System
The location is in the midline “Thoro-columnar”
The origin of its neuron is in the cranuim
It has a slow effect
The receptor organ is near to post ganglion
The Receptors Beta2 can be found in;
- Smooth muscle (Gastrointestinal tract): Decreased gastrointestinal tone and motility
- Lungs: Bronchodilation
- Uterus: Relaxation of uterine smooth muscle
- Liver: Activation of glycogenolysis, Increase blood sugar
What is the receptor and therapeutic uses of Isoproterenol
The receptor organ of Isoproterenol is the B1 and B2 that is commonly use in emergency to Increase the heart rate, the force of contraction, and conduction
