Autonomic Nervous System Agonists and Antagonists Flashcards
What is phenylephrine?
Alpha 1 Agonist
Therapeutic effect of phenylephrine?
Decrease in nasal congestion
Maintain BP
Max number of days to use phenylephrine?
3 days
Where are Beta 2 receptors located?
Lungs
Arterioles
Uterus
Liver
GI Tract
Where are Beta 1 receptors located?
Heart
Coronary Vessels
Kidneys
What are the Adrenergic Receptors?
Alpha 1
Alpha 2
Beta 1
Beta 2
3 Ways to inactive neurotransmitter?
Diffusion
Re-uptake
Enzyme degradation or transformation
What is the parasympathetic system neurotransmitter?
acetylcholine
Where are muscarinic receptors located?
Internal organs
Where are nicotinic receptors located?
Skeletal Muscles
Motor Nerves
What are the cholinergic receptors?
Muscarinic
Nicotinic
What is a cholinergic crisis?
Excessive parasympathetic stimulation
-miosis
-N/V
-urinary incontinence
-increase in secretions
-tachycardia then bradycardia
-hyperglycemia
What medication do you give in cholinergic crisis?
Atropine
What to adrenergic antagonists do?
Block SNS
Decrease Heart Rate, BP and Anxiety
What is a cholinergic agonist medication?
bethanechol
What are the therapeutic effects of epinephrine?
Decrease allergic reactions
Treat anaphylaxis
Is epinephrine selective or nonselective?
nonselective
What are the therapeutic effects of propranolol?
Decrease hypertension, angina, and anxiety
Side effects of propranolol?
IMPOTENCE
hypoglycemia in diabetics
What is propranolol?
beta adrenergic antagonist
(nonselective for beta 1 or beta 2)
What is prazosin?
Alpha 1 antagonist
What are the therapeutic effects of prazosin?
Lower HTN, treat BPH, and PTSD
What are the therapeutic effects of bethanecol?
decrease urine retention
increase peristalsis and GI secretions
What is albuterol?
Beta 2 agonist
Therapeutic effects of albuterol?
improve asthma, COPD
What are 3 Adrenergic Agonists?
Albuterol
Epinephrine
Phenylephrine
Where are Alpha 1 Receptors located?
Blood vessels
Eyes
Bladder
Prostate
Where are Alpha 2 Receptors located?
Blood Vessels
Smooth Muscle (GI)
What is the neurotransmitter for the sympathetic nervous system?
Norepinephrine
What medication is a muscarinic antagonist?
atropine sulfate
What are the therapeutic effects of atropine sulfate?
Increase HR
Dilate pupils
Dry secretions
Slow GI tract
Treat cholinergic crisis
Sxs of anticholinergic?
Can’t Pee
Can’t See
Can’t Spit
Can’t Shit
Beta 1 Agonist sxs?
Increased Heart Rate
Increased BP
Increased Renin secretion
Beta 2 Agonists sxs?
Bronchiole dilation
Decreased GI motility
Increased blood flow to skeletal muscles
Increase blood glucose
Alpha 2 Agonists sxs?
Decrease in vasoconstriction
Decrease in BP
Decrease in GI motility
Alpha 1 Agonists sxs?
Increase force of heart contraction
vasoconstriction
Increase BP
Pupil Dilation
Prostate contraction and ejaculation
