Autonomic Nervous System Flashcards
Afferent neurons of the ANS respond to what stimuli?
Stretch, Glucose, PCO2, PO2, Osmolarity and pH, Temperature
What are the cells involved in a typical sympathetic nervous system pathway?
Preganglionic neuron, postganglionic neuron, target cell
What kind of neuron is the preganglionic neuron in a typical sympathetic nervous pathway? The postganglionic?
Cholinergic; Adrenergic
To what kind of cholinergic receptor will ACh bind on the postganglionic neuron in the sympathtic nervous system?
Nicotinic (N2); muscarinic at some sweat glands and vessels
To what kind of receptor will norepinephrine bind on the target cell?
Alpha- or beta- adrenergic receptors
What events occur upon binding of NE to an adrenergic receptor with an alpha-q subunit?
Phospholipase C converts PIP2 to IP3 and DAG; IP3 increases Ca++ cpncentration in the cytosol
The binding of NE to a receptor with what kind of alpha subunit will result in inhibition of adenylyl cyclase activity?
Alpha I
What events occur upon binding of NE to an adrenergic receptor with an alpha-s subunit?
Increased adenylyl cyclase activity and increased cAMP concentration
Where are adrenergic receptors with alpha-s subunits found?
Heart, smooth muscle and adipose muscle
What kind of neuron is the preganglionicneuron in a typical parasympathetic nervous pathway? The postsympathetic?
Cholinergic; Cholinergic
To what kind of receptor will ACh released by a parasympathetic postsynaptic neroun bind on the target cell?
Muscarinic receptor
What type of cholinergic receptor is a GPCR?
Muscarinic receptors
What are the 2 networks of the enteric nervous system? What do they each control
Myenteric (motility) and Submucosal(secretion)
What kind of neurons connect the motor and sensory components of the enteric nervous system?
Interneurons
What is the main neurotransmitter utilized by the enteric nervous system?
Acetylcholine
