Autonomic Nervous System Flashcards
What does the ANS innervate?
Cardiac muscle, smooth muscle, and secretory cells
Is there direct control involved in ANS?
No, they are under autonomic function
Fight or Flight
Sympathetic
Rest and Digest
Parasympathetic
What does the Somatic nervous system innervate?
Skeletal muscle
Where is the PSNS origin in the spinal cord?
Craniosacral
Where is the SNS origin in the spinal cord?
Thoracolumbar
What are some ANS neurotransmitters?
Acetylcholine Norepinepherine Epinepherine Dopamine Histamine Seratonin NO Etc...
Is acetylcholine released from a presynaptic or postsynaptic neuron?
Presynaptic
What are the two types of cholinergic receptors?
Nicotinic and Muscarinic
**Remember acetylcholine binds to these
What type of receptor are Nicotinic receptors? (ionotropic or metabotropic)
Ionotropic
What type of receptor are Muscarinic receptors? (ionotropic or metabotropic)
Metabotropic
What binds to adrenergic receptors?
Epinepherine, norepinepherine, dopamine
What are the two types of adrenergic receptors?
Alpha (1 and 2) and Beta (1 and 2)
Mimetics
Drugs that stimulate (mimic) Autonomic effects
So,
For parasympathomimetic you will have parasympathetic signs and for sympathetomimetic you will have sympathetic signs
Lytics
Drugs that block autonomic effects
So,
For parasympatholytic you will see sympathetic signs and for sympatholytic you will see parasympathetic signs
Sympathetic effects of the eye
Relaxation of the ciliary muscle and contraction of the iris radial muscle (mydriasis)
Parasympathetic effects of the eye
Contraction of ciliary muscles and iris sphincter muscle
Sympathetic effects of the heart (B-1)
Increased heart rate (tachycardia)
Increased contractility
Increased automacity and conduction of AV node
Parasympathetic effects of the heart
Decreased heart rate (bradycardia)
Decreased contractility
Decreased AV node conduction
Sympathetic effects of the vasculature
a-1 vasoconstriction
b-2 vasodilation
a-2 various
Parasympathetic effects of the vasculature
Vasodilation through release of NO
Sympathetic effects of the lung
b-2 bronchodilation, increase respiratory secretions
a-2 decrease secretions
Parasympathetic effects of the lung
Bronchoconstriction
increase respiratory secretions
Sympathetic effects of the GI tract
a-1, b-1, b-2
decrease motility
close sphincters
inhibit secretion
Parasympathetic effects of the GI tract
increase motility
relax sphincters
stimulate secretions
Sympathetic effects of the bladder
B-2 relax detrusor muscle
a-1 contract sphincter
Parasympathetic effects of the bladder
contract destrusor
relax sphincter
Autonomic drugs can be:
direct acting or indirect acting
What does it mean if an ANS drug is direct acting?
The drug acts directly on the receptor (agonists and antagonists)
What does it mean if an ANS drug is indirect acting?
The drug interacts with something other than the receptor