Autonomic Drugs Flashcards

1
Q

Bethanechol - Action

A

activates Bowel & Bladder smooth muscle
- resistant to AChE

“Beth activates her Bowel & Bladder”

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2
Q

Bethanechol - Clinical uses?

A
  • Postoperative Ileus
  • Neurogenic Ileus
  • Urinary retention
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3
Q

Carbachol - Clinical uses?

A
  • Glaucoma
  • Pupillary contraction
  • Relief of intra-ocular pressure
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4
Q

Carbachol - action?

A

“Carbon copy of Acetylcholine”

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5
Q

Pilocarpine - Clinical uses?

A
  • Potent stimulator of sweat, tears, & saliva

- Open-angle & Closed-angle Glaucoma

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6
Q

Pilocarpine - actions?

A

Contracts ciliary muscle of eye (open-angle glaucoma), pupillary sphincter (closed-angle glaucoma)
- resistant to AChE

“You cry, sweat, & drool on your PILOw”

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7
Q

Methacholine - Clinical uses?

A

Challenge test for diagnosis of asthma

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8
Q

Methacholine - actions?

A

Stimulates muscarinic receptors in airway when inhaled

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9
Q

Neostigmine - Clinical uses?

A
  • Postoperative & Neurogenic Ileus
  • Urinary retention
  • Myasthenia gravis
  • Reversal of neuromuscular junction blockade (postoperative)
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10
Q

Neostigmine - actions?

A
  • Anti-AChE
  • ↑ endogenous ACh

“Neo CNS = No CNS penetration”

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11
Q

Pyridostigmine - Clinical uses?

A
Myasthenia gravis (long-acting)
- does not penetrate CNS
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12
Q

Pyridostigmine - actions?

A
  • Anti-AChE
  • ↑ endogenous ACh
  • ↑ strength

“pyRIDostigmine gets RID of myasthenia gravis)

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13
Q

Edrophonium - Clinical uses?

A

Diagnosis of myasthenia gravis (extremely short-acting)

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14
Q

Edrophonium - actions?

A
  • Anti-AChE

- ↑ endogenous ACh

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15
Q

Physostigmine - Clinical uses?

A

Anticholinergic toxicity

crosses blood-brain barrier → CNS

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16
Q

Physostigmine - actions?

A
  • Anti-AChE
  • ↑ endogenous ACh

“Physostigmine phyxes Cleopatra’s atropine overdose, next to the sphynx”

17
Q

Donepezil - Clinical uses?

A

Alzheimer’s Disease

18
Q

Donepezil - actions?

A
  • Anti-AChE

- ↑ endogenous ACh

19
Q

Symptoms of Cholinesterase-inhibitor poisoning (organophosphates)

A

Diarrhea, Urination, Miosis, Bronchospasm, Bradycardia, Excitation of skeletal muscle & CNS, Lacrimation, Sweating, Salivation

“DUMBBELSS”