Autonomic Drugs

Question 1

How do Gs class receptors work?

Answer 1

Gs activates adenylase cyclase which converts ATP to cAMP. Increase in cAMP activates protein kinase A which increases intercellular calcium in the heart and inhibits myosin light chain kinase in smooth muscle

Question 2

How do Gq linked 2nd messengers function?

Answer 2

When Gq is activated it activates phospholipase C which converts PIP2-> IP3 and DAG. DAG activates protein kinase C which phosphorylates downstream targets. IP3 increases intercellular Ca2+ concentration which causes contraction