Autonomic and NMJ pharmacology Flashcards
role of presynaptic autoreceptors in synaptic transmission in the Autonomic nervous system?
inhibit transmitter release by closing the calcium channels
how does anticholinesterase work?
blocks aceytlcholinestarse which means it stops the break down of Ach therefore Ach stays in the synaptic cleft for longer
How can you make the NMJ work better?
prolong the action potential by having more Ca and allow Ach to stay in the synapse for longer
clinically what can anticholinesterase be used for /
treating myasthenic conditions
Why can you activate nicotinic receptors at the ganglion using Nicotine but not at the NMJ?
as nicotine is more potent/effective in the ganglion
what is the effect of a muscarnic agonist & antagonist?
agonist- mimics the effect of the parasympathetic NS
antagonist-blocks the effects of the parasympathetic NS
what is glaucoma ?
high intraoccular pressure
where does the aqueous humour in the eye normally drain?
through the trabecular network into the canal of schelmn
How can drainage of aqueous humour be increased?
Muscarinic agonists - contract ciliary muscle - opening up the trabecular network
Makes the sphincter muscle of the eye contract
What are sympathomimetics
things that make the sympathetic post ganglion work better
Give example of noradrenaline agonist molecules
phenylpherine and sulbutamol
how would you improve ganglionic transmission?
activate nicotinic receptors (more potent in the ganglia than NMJ)
